Fehér E, Görcs T, Burnstock G
First Department of Anatomy, Semmelweis University Medical School, Budapest, Hungary.
Peptides. 1989 Sep-Oct;10(5):945-9. doi: 10.1016/0196-9781(89)90173-3.
Electron microscopic immunocytochemistry was used to identify somatostatin-immunoreactive nerve profiles around the capillary system of the small intestine in the rat and cat. The highest density of somatostatin-immunoreactive nerve profiles was seen in the mucosa, and 25-30% of all immunoreactive profiles were found immediately adjacent to the endothelial cells of capillary blood vessels. About half of the capillary endothelial cells were fenestrated. The majority of the immunoreactive nerve profiles were varicosities, containing synaptic vesicles. These observations suggest that somatostatin might be released from varicose nerve fibers and may contribute to the elevated levels of the peptide measured in portal blood as compared to peripheral blood.
采用电子显微镜免疫细胞化学方法，鉴定大鼠和猫小肠毛细血管系统周围生长抑素免疫反应性神经轮廓。生长抑素免疫反应性神经轮廓密度最高的部位见于黏膜，且在所有免疫反应性轮廓中，有25% - 30%紧邻毛细血管的内皮细胞。约一半的毛细血管内皮细胞有窗孔。大多数免疫反应性神经轮廓为含有突触小泡的膨体。这些观察结果提示，生长抑素可能从曲张的神经纤维释放，并且与外周血相比，这可能是门静脉血中该肽水平升高的原因。
