Fehér E, Fodor M, Fehér J
First Department of Anatomy, Semmelweis University Medical School, Budapest, Hungary.
Gastroenterology. 1992 Jan;102(1):287-94. doi: 10.1016/0016-5085(92)91812-i.
The distribution and the possible source of somatostatin- and substance P-immunoreactive nerve fibers were studied in the liver of the cat by immunocytochemical techniques. Abundant substance P-immunoreactive and a moderate number of somatostatin-immunoreactive nerve fibers were found running around the blood vessels in the perilobular connective tissue. Some somatostatin-immunoreactive nerve cell bodies were also observed in the liver. A moderate number of somatostatin-immunoreactive nerve profiles were found inside the hepatic lobules along the sinusoid endothelial cells and the hepatocytes. The interspace between the axon and hepatocyte and endothelial cells membranes was about 20 nm. Cutting the extrinsic hepatic nerves resulted in marked reduction of substance P-immunoreactive nerves but only a slight reduction of somatostatin-immunoreactive nerves in the liver. These findings provide a morphological basis for the possibility that somatostatin and substance P may act as transmitters or neuromodulators on the neighboring smooth muscle cells of vessels and may regulate the function of the hepatocytes. It is also possible that some of these fibers serve sensory function along the blood vessels.
采用免疫细胞化学技术研究了猫肝脏中生长抑素和P物质免疫反应性神经纤维的分布及可能来源。在小叶周围结缔组织的血管周围发现了丰富的P物质免疫反应性神经纤维和中等数量的生长抑素免疫反应性神经纤维。在肝脏中还观察到一些生长抑素免疫反应性神经细胞体。在肝小叶内沿窦状隙内皮细胞和肝细胞发现了中等数量的生长抑素免疫反应性神经纤维。轴突与肝细胞和内皮细胞膜之间的间隙约为20纳米。切断肝外神经导致肝脏中P物质免疫反应性神经显著减少，但生长抑素免疫反应性神经仅略有减少。这些发现为生长抑素和P物质可能作为血管相邻平滑肌细胞的递质或神经调质并可能调节肝细胞功能提供了形态学依据。也有可能这些纤维中的一些沿血管发挥感觉功能。
