Deng Tuo, Liao Banghua, Tian Ye, Luo Deyi, Liu Jiaming, Jin Tao, Wang Kunjie
Department of Urology Surgery, West China School of Medicine/West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, 610041, Sichuan Province, People's Republic of China.
Urolithiasis. 2015 Jun;43(3):227-31. doi: 10.1007/s00240-015-0761-9. Epub 2015 Mar 10.
The purpose of the study was to evaluate the association between shock wave lithotripsy (SWL) for urinary stone and new-onset diabetes mellitus (DM). A comprehensive data collection was performed in the Pubmed database, Embase database, Chinese Biomedical database, Chinese National Knowledge Infrastructure database and VIP database. Difference in incidence of new-onset DM after SWL between cases and controls was evaluated by odds ratio (OR) with its 95% confidence interval (CI). And summary adjusted risk ratios (RRs) and 95% CIs were calculated to assess the strength of association between SWL and new-onset DM, and then subgroup analyses were conducted. Five studies were included in this meta-analysis. The incidence of new-onset DM after SWL is not higher than that in the population who do not receive SWL [OR = 1.59, 95% CI (0.92, 2.74), P = 0.10]. And statistical association between SWL and new-onset DM could not be found significantly [RR = 1.33, 95% CI (0.83, 2.13), P = 0.24], either. However, body mass index (BMI) [RR = 1.09, 95% CI (1.04, 1.14), P < 0.001] and family history of DM (FHx DM) [RR = 0.35, 95% CI (0.15, 0.80), P = 0.013] were found significantly associated with the development of DM in subgroup analyses. Our data suggests that there is no association between SWL for urinary stone and new-onset DM.
本研究的目的是评估尿路结石冲击波碎石术（SWL）与新发糖尿病（DM）之间的关联。在PubMed数据库、Embase数据库、中国生物医学数据库、中国知网数据库和维普数据库中进行了全面的数据收集。通过比值比（OR）及其95%置信区间（CI）评估病例组和对照组SWL后新发DM的发病率差异。计算汇总调整风险比（RRs）和95%CI以评估SWL与新发DM之间关联的强度，然后进行亚组分析。本荟萃分析纳入了五项研究。SWL后新发DM的发病率不高于未接受SWL的人群[OR = ¹.⁵⁹，95%CI（0.92，2.74），P = 0.10]。并且也未发现SWL与新发DM之间存在显著的统计学关联[RR = 1.33，95%CI（0.83，2.13），P = 0.24]。然而，在亚组分析中发现体重指数（BMI）[RR = 1.09，95%CI（1.04，1.14），P < 0.001]和糖尿病家族史（FHx DM）[RR = 0.35，95%CI（0.15，0.80），P = 0.013]与DM的发生显著相关。我们的数据表明，尿路结石SWL与新发DM之间没有关联。
