Mantovani Alberto, Allavena Paola
A. Mantovani and P. Allavena are at the IRCCS Humanitas Clinical and Research Center and Humanitas University, 20089 Rozzano, Milano, Italy
J Exp Med. 2015 Apr 6;212(4):435-45. doi: 10.1084/jem.20150295. Epub 2015 Mar 9.
Macrophages are essential components of the inflammatory microenvironment of tumors. Conventional treatment modalities (chemotherapy and radiotherapy), targeted drugs, antiangiogenic agents, and immunotherapy, including checkpoint blockade, all profoundly influence or depend on the function of tumor-associated macrophages (TAMs). Chemotherapy and radiotherapy can have dual influences on TAMs in that a misdirected macrophage-orchestrated tissue repair response can result in chemoresistance, but in other circumstances, TAMs are essential for effective therapy. A better understanding of the interaction of anticancer therapies with innate immunity, and TAMs in particular, may pave the way to better patient selection and innovative combinations of conventional approaches with immunotherapy.
巨噬细胞是肿瘤炎症微环境的重要组成部分。传统治疗方式（化疗和放疗）、靶向药物、抗血管生成药物以及免疫疗法（包括检查点阻断），均会对肿瘤相关巨噬细胞（TAM）的功能产生深远影响或依赖于其功能。化疗和放疗对TAM可能具有双重影响，即巨噬细胞介导的组织修复反应若出现偏差可导致化疗耐药，但在其他情况下，TAM对于有效治疗至关重要。更好地理解抗癌疗法与固有免疫尤其是与TAM的相互作用，可能为更好地进行患者选择以及将传统方法与免疫疗法进行创新性联合铺平道路。
