Askar Sherif M, Elnashar Ismail S, El-Anwar Mohammad W, Amer Hazem S, El Shawadfy Mohammad A, Hosny Sameh M, Bazeed Mohamed F, Ahmed Ayman F, Ghanem Mona A
Zagazig University, Zagazig, Egypt
Zagazig University, Zagazig, Egypt.
Otolaryngol Head Neck Surg. 2015 May;152(5):959-63. doi: 10.1177/0194599815573196. Epub 2015 Mar 9.
To evaluate the effect of unilateral nasal obstruction (by nasal polyps of different histopathology) on olfactory bulb volume using MRI technique.
Cross-sectional study.
Tertiary university hospitals, Departments of Otolaryngology and Radiology.
Eleven patients with a few months of complete unilateral nasal obstruction of different pathological etiologies were selected. MRI assessment of olfactory bulb volume was performed using planimetric manual contouring. The contralateral olfactory bulb was used as a comparative control for the same patient. Eleven healthy controls constituted the control group.
Mean olfactory bulb volume ± SD of obstructed side = 14.3 ± 3.7 mm(3), mean olfactory bulb volume ± SD of nonobstructed side = 43.49 ± 10.7 mm(3). The difference between the 2 sides was significant (P = .003). The difference in olfactory bulb volume between normal subjects and nonobstructed nasal side was statistically nonsignificant (t = .9118, P = .3727), while the difference between normal subjects' olfactory bulb volume and obstructed nasal side olfactory bulb volume in our patients was extremely statistically significant (t = 9.7320, P < .0001). A strong negative correlation was found between duration of obstruction and olfactory bulb volume (R = -0.9761).
This study shows that unilateral nasal obstruction may be associated with a lateralized ipsilateral difference of olfactory bulb volume.
使用MRI技术评估单侧鼻阻塞（由不同组织病理学的鼻息肉引起）对嗅球体积的影响。
横断面研究。
三级大学医院的耳鼻喉科和放射科。
选取11例因不同病理病因导致单侧鼻完全阻塞数月的患者。采用手工轮廓测量法对嗅球体积进行MRI评估。将同一患者的对侧嗅球作为对照。选取11名健康对照者组成对照组。
阻塞侧嗅球平均体积±标准差 = 14.3 ± 3.7 mm³，非阻塞侧嗅球平均体积±标准差 = 43.49 ± 10.7 mm³。两侧差异有统计学意义（P = .003）。正常受试者与非阻塞侧鼻侧嗅球体积差异无统计学意义（t = .9118，P = .3727），而正常受试者嗅球体积与患者阻塞侧鼻侧嗅球体积差异有极显著统计学意义（t = 9.7320，P < .0001）。发现阻塞持续时间与嗅球体积之间存在强负相关（R = -0.9761）。
本研究表明单侧鼻阻塞可能与嗅球体积的同侧侧化差异有关。
