Department of Otolaryngology, Faculty of Medicine, Zagazig University, Egypt.
Otolaryngol Head Neck Surg. 2013 Apr;148(4):689-93. doi: 10.1177/0194599813477606. Epub 2013 Feb 11.
The olfactory bulb (OB) is thought to be a plastic structure with highly active afferent neurons. The aim of this study was to evaluate the effect of olfactory deprivation caused by sinonasal polyps on OB volume.
Cross-sectional study.
Tertiary university hospital, Department of Otolaryngology.
Twenty-two subjects were included: 11 adult patients with bilateral allergic sinonasal polyposis (patient group) and 11 adult healthy controls (control group). Both study groups were matched for age and sex. OB volumes in all study subjects were evaluated in T2-weighted coronal MRI images by planimetric manual contouring.
In the patient group, OB volume measurements ranged from 5.2 to 19.5 mm(3) (mean ± SD, 10.14 ± 3.8). In the control group, volume measurements ranged from 35 to 75.8 mm(3) (mean ± SD, 47.66 ± 10.75). The difference in OB volumes between patient and control groups was statistically significant (P < .001).
Our study highlights the significant reduction in OB volume in patients with bilateral sinonasal polyposis as compared with its volume in healthy controls. Further studies are required to evaluate the impact of OB volume reduction on olfactory recovery postoperatively.
嗅球（OB）被认为是具有高度活跃传入神经元的可塑结构。本研究旨在评估因鼻息肉引起的嗅觉丧失对 OB 体积的影响。
横断面研究。
大学附属医院耳鼻喉科。
共纳入 22 名受试者：11 名双侧变应性鼻息肉的成年患者（患者组）和 11 名成年健康对照（对照组）。两组研究对象在年龄和性别上相匹配。所有研究对象的 OB 体积均在 T2 加权冠状 MRI 图像上通过平面手动轮廓测量进行评估。
在患者组中，OB 体积测量值范围为 5.2 至 19.5mm³（平均值 ± SD，10.14 ± 3.8）。在对照组中，体积测量值范围为 35 至 75.8mm³（平均值 ± SD，47.66 ± 10.75）。患者组和对照组之间的 OB 体积差异具有统计学意义（P<.001）。
我们的研究强调了双侧鼻息肉患者 OB 体积明显缩小，与健康对照组相比。需要进一步研究来评估 OB 体积减少对术后嗅觉恢复的影响。
