Dzhambov Angel, Dimitrova Donka
Faculty of Medicine, Medical University of Plovdiv, Bulgaria.
Endokrynol Pol. 2015;66(1):39-46. doi: 10.5603/EP.2015.0007.
Chronic psychological distress can cause suppression of the hypothalamic-pituitary-testicular axis and thus lead to male hypogonadism, which is associated with psycho-social dysfunction, chronic diseases, and as a result, considerable economic costs. Conversely, noise is a prototypal environmental stressor of growing importance, already linked to birth outcomes and diabetes. However, its effects on male testosterone levels have been paid little attention.
This paper reports a systematic review and meta-analysis of experimental studies in rodents, which have examined the effect of chronic noise stress on serum testosterone levels. A systematic search in MEDLINE, EMBASE and the Internet yielded seven studies. A quality effects meta-analytical model was applied to compute pooled Hedges's g. Quality effects meta-regression was carried out as well.
We found pooled Hedges's g of -2.41 (95% CI: -3.28, -1.54), indicating a very large effect of noise exposure on testosterone. Metaregression confirmed that the overall duration of exposure explained a significant proportion of the variance across individual effect sizes (Q (1) = 3.95, p = 0.047). However, there was considerable inter-study heterogeneity (I2 = 82%) and publication bias (p = 0.016). After inputting two studies previously thought to be missing, the pooled effect dropped to g = -1.53 (95% CI: -3.01, -0.05).
Chronic noise exposure of ≈ 100 dB leads to a significant reduction of serum testosterone in male rodents. Research on humans is highly warranted, especially given the steady trend in Western societies for increasing the burden of both male hypogonadism and noise pollution.
慢性心理困扰可导致下丘脑 - 垂体 - 睾丸轴的抑制，进而引发男性性腺功能减退，这与心理社会功能障碍、慢性疾病相关，从而带来相当大的经济成本。相反，噪声是一种日益重要的典型环境应激源，已与出生结局和糖尿病相关联。然而，其对男性睾酮水平的影响却很少受到关注。
本文报告了一项对啮齿动物实验研究的系统评价和荟萃分析，这些研究考察了慢性噪声应激对血清睾酮水平的影响。在MEDLINE、EMBASE和互联网上进行系统检索，得到了七项研究。应用质量效应荟萃分析模型计算合并的Hedges's g值。还进行了质量效应荟萃回归分析。
我们发现合并的Hedges's g值为 -2.41（95%置信区间：-3.28，-1.54），表明噪声暴露对睾酮有非常大的影响。荟萃回归分析证实，暴露的总时长解释了个体效应量方差的很大一部分（Q(1)=3.95，p = 0.047）。然而，研究间存在相当大的异质性（I2 = 82%）和发表偏倚（p = 0.016）。在纳入之前认为缺失的两项研究后，合并效应降至g = -1.53（95%置信区间：-3.01，-0.05）。
约100分贝的慢性噪声暴露会导致雄性啮齿动物血清睾酮显著降低。非常有必要对人类进行研究，特别是考虑到西方社会中男性性腺功能减退和噪声污染负担不断增加的稳定趋势。
