Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
Obesity (Silver Spring). 2015 Apr;23(4):733-6. doi: 10.1002/oby.21034. Epub 2015 Mar 6.
The aim of this study was to investigate whether indicators of metabolic health fluctuate during the week in a group of children posing unhealthier physical activity, sedentary time, and sleep during weekends compared to weekdays.
A total of 807 eight- to eleven-year-old children had valid metabolic health markers from one, two, or three measurements contributing 2190 to 2240 observations of metabolic health markers. The weekly variation was tested using linear mixed models.
Homeostatic model assessment of insulin resistance (HOMAIR), triglycerides, leptin (all P < 0.001), and adiponectin (P = 0.03) decreased from Monday to Friday, whereas ghrelin increased (P < 0.001). HOMAIR , triglycerides, and leptin were 35%, 28%, and 33% higher on Mondays compared to Fridays, respectively, and ghrelin was 7% lower on Mondays compared to Fridays (all P < 0.001).
The large weekly variation in HOMAIR , triglycerides, and leptin was likely the result of unhealthier behaviors during weekends. These findings have public health relevance and raise methodological issues that should ideally be taken into account in future studies.
本研究旨在调查与工作日相比，周末身体活动、久坐时间和睡眠不健康的一组儿童体内代谢健康指标是否存在周内波动。
共有 807 名 8 至 11 岁儿童的代谢健康标志物具有有效性，从一次、两次或三次测量中各有 2190 至 2240 个代谢健康标志物观测值。采用线性混合模型检测每周的变化。
胰岛素抵抗稳态模型评估（HOMAIR）、甘油三酯、瘦素（均 P<0.001）和脂联素（P=0.03）从周一到周五逐渐降低，而生长激素释放肽（ghrelin）增加（P<0.001）。与周五相比，周一的 HOMAIR、甘油三酯和瘦素分别高 35%、28%和 33%，而周一的生长激素释放肽（ghrelin）比周五低 7%（均 P<0.001）。
HOMAIR、甘油三酯和瘦素的大幅周内变化可能是周末不健康行为导致的。这些发现具有公共卫生意义，并提出了一些方法学问题，在未来的研究中最好能考虑到这些问题。
