青少年血清脑源性神经营养因子与一系列心血管危险因素之间的关联：CHAMPS-研究丹麦队列
The association between serum brain-derived neurotrophic factor and a cluster of cardiovascular risk factors in adolescents: The CHAMPS-study DK.
作者信息
Pedersen Natascha Holbæk, Tarp Jakob, Andersen Lars Bo, Gejl Anne Kær, Huang Tao, Peijs Lone, Bugge Anna
机构信息
Centre of Research in Childhood Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
Department of Teacher Education and Sport, Western Norway University of Applied Sciences, Campus Sogndal, Norway.
出版信息
PLoS One. 2017 Oct 13;12(10):e0186384. doi: 10.1371/journal.pone.0186384. eCollection 2017.
BACKGROUND AND OBJECTIVE
Cardiovascular disease and type 2 diabetes pose a global health burden. Therefore, clarifying the pathology of these risk factors is essential. Previous studies have found positive and negative associations between one or more cardiovascular risk factors and brain-derived neurotrophic factor (BDNF) probably due to diverse methodological approaches when analysing peripheral BDNF levels. Moreover, only a few studies have been performed in youth populations. Consequently, the main objective of this study was to examine the association between serum BDNF and a composite z-score consisting of six cardiovascular risk factors. A secondary aim was to examine the associations between serum BDNF and each of the six risk factors.
METHODS
Four hundred and forty-seven apparently healthy adolescents between 11-17 years of age participated in this cross-sectional study. Cardiorespiratory fitness (CRF), anthropometrics, pubertal status, blood pressure (BP), serum BDNF, high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), blood glucose and insulin were measured. Information about alcohol consumption and socio-economic status was collected via questionnaires. Associations were modelled using linear regression analysis.
RESULTS
Serum BDNF was positively associated with the composite z-score in the total study sample (standardized beta coefficient (std.β) = 0.10, P = 0.037). In males, serum BDNF was positively associated with the composite z-score (Std. β = 0.14, P = 0.034) and HOMA-IR (Std. β = 0.19, P = 0.004), and negatively associated with CRF (Std. β = -0.15, P = 0.026). In females, BDNF was positively associated with TG (Std. β = 0.14, P = 0.030) and negatively associated with waist circumference (WC) (Std. β = -0.16, P = 0.012).
CONCLUSION
Serum BDNF was positively associated with a composite z-score of cardiovascular risk factors. This association seems to be mainly driven by the association between TG, HOMA-IR and serum BDNF, and particularly for males. Further longitudinal research is warranted to determine the temporal relationship between BDNF and cardiovascular risk factors.
背景与目的
心血管疾病和2型糖尿病给全球健康带来负担。因此，阐明这些危险因素的病理机制至关重要。以往研究发现，分析外周脑源性神经营养因子（BDNF）水平时，由于方法多样，一种或多种心血管危险因素与BDNF之间存在正相关和负相关。此外，针对青少年人群的研究较少。因此，本研究的主要目的是探讨血清BDNF与由六个心血管危险因素组成的综合z评分之间的关联。次要目的是研究血清BDNF与六个危险因素中的每一个之间的关联。
方法
447名11至17岁表面健康的青少年参与了这项横断面研究。测量了心肺适能（CRF）、人体测量学指标、青春期状态、血压（BP）、血清BDNF、高密度脂蛋白胆固醇（HDL-C）、甘油三酯（TG）、血糖和胰岛素。通过问卷调查收集饮酒和社会经济状况信息。采用线性回归分析建立关联模型。
结果
在整个研究样本中，血清BDNF与综合z评分呈正相关（标准化β系数（std.β）=0.10，P=0.037）。在男性中，血清BDNF与综合z评分（Std.β=0.14，P=0.034）和胰岛素抵抗指数（HOMA-IR）（Std.β=0.19，P=0.004）呈正相关，与CRF呈负相关（Std.β=-0.15，P=0.026）。在女性中，BDNF与TG呈正相关（Std.β=0.14，P=0.030），与腰围（WC）呈负相关（Std.β=-0.16，P=0.012）。
结论
血清BDNF与心血管危险因素的综合z评分呈正相关。这种关联似乎主要由TG、HOMA-IR与血清BDNF之间的关联驱动，尤其是在男性中。有必要进行进一步的纵向研究，以确定BDNF与心血管危险因素之间的时间关系。
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