新加坡华人、印度人和马来人的组织型纤溶酶原激活剂限制性片段长度多态性

Tissue-type plasminogen activator restriction fragment length polymorphism in the Chinese, Indians and Malays of Singapore.

作者信息

Saha N

机构信息

Department of Paediatrics, Faculty of Medicine, National University of Singapore.

出版信息

Hum Hered. 1989;39(6):364-6. doi: 10.1159/000153890.

DOI:10.1159/000153890

PMID:2575596

Abstract

A total of 215 subjects comprising 95 Chinese, 66 Malays and 54 Indians were investigated for restriction fragment length polymorphisms of the tissue-type plasminogen activator (PLAT) gene at an EcoRI site using the probe ptPA-4352. The phenotypic distribution showed a good agreement with the Hardy-Weinberg equilibrium. The gene frequencies of PLAT*1 were found to be 0.47 in the Chinese, 0.52 in the Malays and 0.41 in South Indians.

摘要

使用探针ptPA - 4352，对总共215名受试者进行了组织型纤溶酶原激活剂（PLAT）基因在EcoRI位点的限制性片段长度多态性研究，其中包括95名中国人、66名马来人和54名印度人。表型分布与哈迪 - 温伯格平衡表现出良好的一致性。发现PLAT*1的基因频率在中国人中为0.47，在马来人中为0.52，在南印度人中为0.41。