Furuta Michiko, Shimazaki Yoshihiro, Tanaka Shunichi, Takeuchi Kenji, Shibata Yukie, Takeshita Toru, Nishimura Fusanori, Yamashita Yoshihisa
Section of Preventive and Public Health Dentistry, Division of Oral Health, Growth and Development, Kyushu University Faculty of Dental Science, Fukuoka 812-8582, Japan.
Section of Preventive and Public Health Dentistry, Division of Oral Health, Growth and Development, Kyushu University Faculty of Dental Science, Fukuoka 812-8582, Japan ; Department of Preventive Dentistry and Dental Public Health, School of Dentistry, Aichi-Gakuin University, Nagoya 464-8650, Japan.
Biomed Res Int. 2015;2015:897971. doi: 10.1155/2015/897971. Epub 2015 Jan 31.
It remains unclear whether serum antibody titer against Porphyromonas gingivalis (Pg) and inflammatory components lead to periodontal deterioration in each gender, as periodontal and systemic status is influenced by gender. The present study investigates the gender-specific probable effects of titer against Pg and inflammatory markers on periodontal health status in a longitudinal study. A retrospective study design was used. At two time points over an 8-year period (in 2003 and 2011), 411 individuals (295 males with a mean age of 57.6 ± 11.2 years and 116 females with a mean age of 59.2 ± 10.3 years) were surveyed. Periodontal status, serum antibody titer against Pg, and high-sensitive C-reactive protein (hsCRP) were evaluated. Poisson regression analyses revealed that the elevated titer against Pg and hsCRP significantly predicted the persistence of periodontal disease 8 years later in females with periodontal disease in 2003. Elevated hsCRP was significantly associated with the incidence of periodontal disease 8 years later in females who were periodontally healthy in 2003. Males had a weaker association among titer against Pg, inflammatory markers, and periodontal disease. These findings suggest that immune response to Pg infection in addition to inflammatory components affects periodontal deterioration in females.
由于牙周和全身状况受性别影响，针对牙龈卟啉单胞菌（Pg）的血清抗体滴度和炎症成分是否会导致不同性别的牙周恶化仍不清楚。本研究在一项纵向研究中调查了针对Pg的滴度和炎症标志物对牙周健康状况的性别特异性可能影响。采用回顾性研究设计。在8年期间的两个时间点（2003年和2011年），对411名个体（295名男性，平均年龄57.6±11.2岁；116名女性，平均年龄59.2±10.3岁）进行了调查。评估了牙周状况、针对Pg的血清抗体滴度和高敏C反应蛋白（hsCRP）。泊松回归分析显示，2003年患有牙周疾病的女性中，针对Pg的滴度升高和hsCRP显著预测了8年后牙周疾病的持续存在。hsCRP升高与2003年牙周健康的女性8年后牙周疾病的发病率显著相关。男性中针对Pg的滴度、炎症标志物和牙周疾病之间的关联较弱。这些发现表明，除炎症成分外针对Pg感染的免疫反应会影响女性的牙周恶化。
