Department of Biomedical Sciences, School of Dental Medicine, University of Nevada Las Vegas and Department of Periodontology, College of Dentistry, University of Kentucky, United States.
Department of Biomedical Sciences, School of Dental Medicine, University of Nevada Las Vegas and Department of Periodontology, College of Dentistry, University of Kentucky, United States.
Immunol Lett. 2020 Feb;218:11-21. doi: 10.1016/j.imlet.2019.12.004. Epub 2019 Dec 18.
Aging humans display an increased prevalence and severity of periodontitis, although the mechanisms underlying these findings remain poorly understood. This report examined antigenic diversity of P. gingivalis related to disease presence and patient demographics. Serum IgG antibody to P. gingivalis strains ATCC33277, FDC381, W50 (ATCC53978), W83, A7A1-28 (ATCC53977) and A7436 was measured in 426 participants [periodontally healthy (n = 61), gingivitis (N = 66) or various levels of periodontitis (N = 299)]. We hypothesized that antigenic diversity in P. gingivalis could contribute to a lack of "immunity" in the chronic infections of periodontal disease. Across the strains, the antibody levels in the oldest age group were lower than in the youngest groups, and severe periodontitis patients did not show higher antibody with aging. While 80 % of the periodontitis patients in any age group showed an elevated response to at least one of the P. gingivalis strains, the patterns of individual responses in the older group were also substantially different than the other age groups. Significantly greater numbers of older patients showed strain-specific antibody profiles to only 1 strain. The findings support that P. gingivalis may demonstrate antigenic diversity/drift within patients and could be one factor to help explain the inefficiency/ineffectiveness of the adaptive immune response in managing the infection.
衰老人群中牙周炎的发生率和严重程度增加，尽管这些发现背后的机制仍知之甚少。本报告研究了与疾病存在和患者人口统计学相关的牙龈卟啉单胞菌的抗原多样性。在 426 名参与者中测量了针对牙龈卟啉单胞菌菌株 ATCC33277、FDC381、W50（ATCC53978）、W83、A7A1-28（ATCC53977）和 A7436 的血清 IgG 抗体[牙周健康（n=61）、牙龈炎（n=66）或不同程度的牙周炎（n=299）]。我们假设牙龈卟啉单胞菌的抗原多样性可能导致牙周病慢性感染中缺乏“免疫力”。在所有菌株中，年龄最大组的抗体水平低于最年轻组，且严重牙周炎患者的抗体水平并未随年龄增长而升高。虽然任何年龄组的 80%的牙周炎患者对至少一种牙龈卟啉单胞菌菌株的反应升高，但老年组的个体反应模式也与其他年龄组明显不同。明显更多的老年患者对仅 1 种菌株表现出特异性抗体谱。这些发现支持牙龈卟啉单胞菌在患者体内可能表现出抗原多样性/漂移，并且可能是有助于解释适应性免疫反应在控制感染方面效率低下/无效的一个因素。
