†Key Laboratory of Biomedical Polymers of Ministry of Education, College of Chemistry and Molecular Science, Wuhan University, Wuhan, Hubei 430072, P. R. China.
‡College of Chemistry and Chemical Engineering, Luoyang Normal University, Luoyang, Henan 471022, P. R. China.
ACS Appl Mater Interfaces. 2015 Apr 1;7(12):7008-15. doi: 10.1021/acsami.5b01210. Epub 2015 Mar 18.
This work presented a highly efficient antibacterial Ti-surface which was grafted with poly(N-hydroxyethylacrylamide) (PHEAA) brush and further decorated with triclosan (TCS). The modified surfaces were characterized using contact angle measurements, X-ray photoelectron spectroscopy, and attenuated total reflectance Fourier transform infrared. The antibacterial performance of the modified surfaces was evaluated using the Streptococcus mutans and Actinomyces naeslundii attachment test. The Ti surface with PHEAA brush (Ti-PHEAA) was able to resist the adhesion of the bacteria, while the TCS-decorated Ti surface (Ti-TCS) showed the capability of killing the bacteria adhered on the surface. As we coupled the TCS to the PHEAA brush, the surface showed highly efficient antibacterial performance due to the combination of the resistance to the bacteria adhesion and its activity of killing bacteria.
这项工作制备了一种高效的抗菌 Ti 表面，该表面接枝了聚（N-羟乙基丙烯酰胺）（PHEAA）刷，进一步用三氯生（TCS）修饰。使用接触角测量、X 射线光电子能谱和衰减全反射傅里叶变换红外对修饰表面进行了表征。使用变形链球菌和奈瑟氏放线菌附着试验评估了改性表面的抗菌性能。具有 PHEAA 刷的 Ti 表面（Ti-PHEAA）能够抵抗细菌的附着，而用 TCS 修饰的 Ti 表面（Ti-TCS）显示出杀死附着在表面上的细菌的能力。由于我们将 TCS 偶联到 PHEAA 刷上，因此由于抵抗细菌附着的能力及其杀死细菌的活性，表面表现出了高效的抗菌性能。
