Ren Chengcheng, Li Xiaobo, Wang Tianzhen, Wang Guangyu, Zhao Ci, Liang Tian, Zhu Yuanyuan, Li Minghui, Yang Chao, Zhao Yunlong, Zhang Guang-mei
*Harbin Medical University, Harbin, China; †The First Affiliated Hospital of Harbin Medical University, Harbin, China; ‡The Affiliated Tumor Hospital of Harbin Medical University, Harbin, China; and §Inner Mongolia Medical College, Hohhot, China.
Int J Gynecol Cancer. 2015 May;25(4):566-9. doi: 10.1097/IGC.0000000000000413.
Long noncoding RNAs (lncRNAs) are longer than 200-nucleotide, noncoding transcripts in length, have a variety of biological functions, and are closely associated with tumor development. Ovarian cancer, as 1 of the 3 common gynecological malignancies, is the leading cause of death in women with gynecological malignant tumor. In this study, a review of the literature found that lncRNAs H19, LSINCT5, and XIST have a close relationship to the development of ovarian cancer occurrence, growth, invasion, and metastasis, and they can promote ovarian cancer cell proliferation. Hence, in this article, the progress of above-mentioned 3 kinds of lncRNAs in ovarian cancer was reviewed and designed to help in the diagnosis, treatment, and prognosis of ovarian cancer.
长链非编码RNA（lncRNAs）是长度超过200个核苷酸的非编码转录本，具有多种生物学功能，且与肿瘤发展密切相关。卵巢癌作为三大常见妇科恶性肿瘤之一，是妇科恶性肿瘤女性患者的主要死因。在本研究中，通过文献回顾发现lncRNAs H19、LSINCT5和XIST与卵巢癌的发生、生长、侵袭和转移密切相关，并且它们能够促进卵巢癌细胞增殖。因此，本文对上述3种lncRNAs在卵巢癌中的研究进展进行综述，旨在为卵巢癌的诊断、治疗及预后提供帮助。
