长链非编码RNA在卵巢癌中的功能与机制
Functions and Mechanisms of Long Noncoding RNAs in Ovarian Cancer.
作者信息
Ren Chengcheng, Li Xiaobo, Wang Tianzhen, Wang Guangyu, Zhao Ci, Liang Tian, Zhu Yuanyuan, Li Minghui, Yang Chao, Zhao Yunlong, Zhang Guang-mei
机构信息
*Harbin Medical University, Harbin, China; †The First Affiliated Hospital of Harbin Medical University, Harbin, China; ‡The Affiliated Tumor Hospital of Harbin Medical University, Harbin, China; and §Inner Mongolia Medical College, Hohhot, China.
出版信息
Int J Gynecol Cancer. 2015 May;25(4):566-9. doi: 10.1097/IGC.0000000000000413.
Long noncoding RNAs (lncRNAs) are longer than 200-nucleotide, noncoding transcripts in length, have a variety of biological functions, and are closely associated with tumor development. Ovarian cancer, as 1 of the 3 common gynecological malignancies, is the leading cause of death in women with gynecological malignant tumor. In this study, a review of the literature found that lncRNAs H19, LSINCT5, and XIST have a close relationship to the development of ovarian cancer occurrence, growth, invasion, and metastasis, and they can promote ovarian cancer cell proliferation. Hence, in this article, the progress of above-mentioned 3 kinds of lncRNAs in ovarian cancer was reviewed and designed to help in the diagnosis, treatment, and prognosis of ovarian cancer.
长链非编码RNA（lncRNAs）是长度超过200个核苷酸的非编码转录本，具有多种生物学功能，且与肿瘤发展密切相关。卵巢癌作为三大常见妇科恶性肿瘤之一，是妇科恶性肿瘤女性患者的主要死因。在本研究中，通过文献回顾发现lncRNAs H19、LSINCT5和XIST与卵巢癌的发生、生长、侵袭和转移密切相关，并且它们能够促进卵巢癌细胞增殖。因此，本文对上述3种lncRNAs在卵巢癌中的研究进展进行综述，旨在为卵巢癌的诊断、治疗及预后提供帮助。
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