Gametogenesis Research Center, Kashan University of Medical Sciences, Kashan, Iran.
Normandie Univ, UNICAEN, INSERM, ANTICIPE U1086 (Interdisciplinary Research for Cancers prevention and treatment, axis BioTICLA (Biology and Innovative Therapeutics for Ovarian Cancer), Caen, France.
Mol Cancer. 2017 Jun 21;16(1):107. doi: 10.1186/s12943-017-0671-2.
Cancers of the female reproductive system include ovarian, uterine, vaginal, cervical and vulvar cancers, which are termed gynecologic cancer. The emergence of long noncoding RNAs (lncRNAs), which are believed to play a crucial role in several different biological processes, has made the regulation of gene expression more complex. Although the function of lncRNAs is still rather elusive, their broad involvement in the initiation and progression of various cancers is clear. They are also involved in the pathogenesis of cancers of the female reproductive system. LncRNAs play a critical physiological role in apoptosis, metastasis, invasion, migration and cell proliferation in these cancers. Different expression profiles of lncRNAs have been observed in various types of tumors compared with normal tissues and between malignant and benign tumors. These differential expression patterns may lead to the promotion or suppression of cancer development and tumorigenesis. In the current review, we present the lncRNAs that show a differential expression between cancerous and normal tissues in ovarian, cervical and endometrial cancers, and highlight the associations between lncRNAs and some of the molecular pathways involved in these cancers.
女性生殖系统癌症包括卵巢癌、子宫癌、阴道癌、宫颈癌和外阴癌，这些癌症被称为妇科癌症。长链非编码 RNA（lncRNA）的出现，被认为在几种不同的生物学过程中发挥着关键作用，使得基因表达的调控更加复杂。尽管 lncRNA 的功能仍然相当难以捉摸，但它们广泛参与各种癌症的发生和发展是显而易见的。它们也参与女性生殖系统癌症的发病机制。lncRNA 在这些癌症中的细胞凋亡、转移、浸润、迁移和细胞增殖中起着至关重要的生理作用。与正常组织相比，不同类型的肿瘤以及恶性肿瘤和良性肿瘤之间观察到 lncRNA 的表达谱存在差异。这些差异表达模式可能导致癌症的发生和肿瘤发生的促进或抑制。在本综述中，我们展示了在卵巢癌、宫颈癌和子宫内膜癌中癌组织与正常组织之间差异表达的 lncRNA，并强调了 lncRNA 与这些癌症中涉及的一些分子途径之间的关联。
