源自扁枝藻的乙酸盐衍生代谢物。
Acetate-Derived Metabolites from the Brown Alga Lobophora variegata.
机构信息
†Institute for Bio-Organic Chemistry "Antonio González", Center for Biomedical Research of the Canary Islands (CIBICAN), Department of Organic Chemistry, University of La Laguna, 38206 La Laguna, Tenerife, Spain.
§Centre for Drug Research, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, FI-00014 Helsinki, Finland.
出版信息
J Nat Prod. 2015 Jul 24;78(7):1716-22. doi: 10.1021/acs.jnatprod.5b00415. Epub 2015 Jul 1.
Seven new nonadecaketides (1-7), lobophorols A-C, lobophopyranones A and B, and lobophorones A and B, along with the first naturally occurring related metabolites (8-10), were isolated from specimens of Lobophora variegata collected from the Canary Islands. Their structures were determined by extensive spectroscopic methods. In addition, an insight into the biosynthesis of these compounds on the basis of the involvement of type III polyketide synthases is proposed. Lobophorol A (1) showed significant antibacterial activity against Staphylococcus aureus.
从加那利群岛采集的斑叶藻属（Lobophora variegata）标本中分离得到了 7 个新的十九烷（1-7）、 lobophorols A-C、lobophopyranones A 和 B 以及 lobophorones A 和 B，以及第一个天然存在的相关代谢物（8-10）。通过广泛的光谱方法确定了它们的结构。此外，还根据 III 型聚酮合酶的参与提出了这些化合物生物合成的深入了解。Lobophorol A（1）对金黄色葡萄球菌表现出显著的抗菌活性。
Zotero 插件