Saroyan John M, Evans Elizabeth A, Segoshi Andrew, Vosburg Suzanne K, Miller-Saultz Debra, Sullivan Maria A
*Bayada Hospice. Norwich, VT †New York State Psychiatric Institute ‡Division on Substance Abuse, Department of Psychiatry, Columbia University Medical Center §Columbia University of Nursing, New York, New York ∥Alkermes, Inc., Waltham, MA.
Clin J Pain. 2016 Jan;32(1):1-6. doi: 10.1097/AJP.0000000000000231.
Many adolescents and young adults report having chronic pain. Urine drug toxicology (UDT) is not routinely used in the pediatric pain management population, despite more routine use in adults with pain, particularly those prescribed opioids. As a first step toward establishing monitoring practices in pediatric and adolescent pain management, the present study evaluated the role of UDT in conjunction with a standard clinical interview in identifying the rate of adherence to an established analgesic regimen. The study also aimed to assess the use of UDT in identifying possible aberrant behaviors in this population.
Data were acquired from a convenience sample of 50 pediatric and adolescent pain management initial consultations, during which a clinical interview and UDT were conducted. Data were analyzed to determine adherence to an established analgesic prescription regimen, and for identification of aberrant behaviors including concurrent use of illicit substances and prescription medication misuse. Other pertinent demographic and clinical factors were examined as factors in adherence.
Opioid medications were prescribed for 42% of the sample receiving pain medications, and 22% of the sample was nonadherent to their prescription analgesic regimen. Factors associated with a higher likelihood of nonadherence were an older age and having an opioid prescription. The majority (90%) of those nonadherent to their analgesic regimen displayed some form of aberrant behavior. Among the nonadherent patients, 50% were identified by UDT alone, and 50% were identified by self-report during the clinical encounter.
These results highlight the challenges of identifying nonadherence to a prescription regimen among adolescents with chronic pain. In addition, this preliminary work suggests that UDT could be used in conjunction with careful clinical interviewing to substantiate patient report and increase the likelihood of detecting analgesic nonadherence and aberrant behaviors.
许多青少年和青年报告患有慢性疼痛。尽管尿液药物毒理学(UDT)在疼痛的成年患者中使用更为常规,尤其是那些开具了阿片类药物处方的患者,但在儿科疼痛管理人群中并未常规使用。作为在儿科和青少年疼痛管理中建立监测实践的第一步,本研究评估了UDT结合标准临床访谈在确定既定镇痛方案依从率方面的作用。该研究还旨在评估UDT在识别该人群中可能存在的异常行为方面的应用。
数据来自50例儿科和青少年疼痛管理初次咨询的便利样本,在此期间进行了临床访谈和UDT检测。对数据进行分析,以确定对既定镇痛处方方案的依从性,并识别包括同时使用非法物质和误用处方药在内的异常行为。还检查了其他相关的人口统计学和临床因素作为依从性的因素。
接受疼痛药物治疗的样本中有42%开具了阿片类药物,22%的样本未遵守其处方镇痛方案。与不依从可能性较高相关的因素是年龄较大和开具了阿片类药物处方。大多数(90%)未遵守镇痛方案的患者表现出某种形式的异常行为。在不依从的患者中,50%仅通过UDT检测被识别,50%在临床问诊期间通过自我报告被识别。
这些结果凸显了识别慢性疼痛青少年中不遵守处方方案的挑战。此外,这项初步工作表明,UDT可与仔细的临床访谈结合使用,以证实患者报告,并增加检测到镇痛不依从和异常行为的可能性。