Stuckey Melanie I, Gill Dawn P, Petrella Robert J
Lawson Health Research Institute, Aging Rehabilitation and Geriatric Care Research Centre, London, ON.
J Clin Hypertens (Greenwich). 2015 May;17(5):375-80. doi: 10.1111/jch.12531. Epub 2015 Mar 10.
The purpose of this study was to determine whether responders (minimum 4-mm Hg reduction of systolic blood pressure [BP]) at 24 weeks) to a 52-week lifestyle intervention had greater changes in metabolic risk factors and health-related quality of life than nonresponders. Participants (N=126; age, 57.4 [9.1] years) had waist circumference (WC), resting BP, glycated hemoglobin, lipids, and fitness assessed at baseline and at 12, 24, and 52 months. The 36-item short-form survey was administered to assess HRQOL. At baseline, responders had higher mental health scores (P=.04) and systolic and diastolic BPs (P<.001) than nonresponders. Across 52 weeks, responders also had greater improvements in diastolic BP (P<.001), WC (P=.01), and maximal oxygen uptake (P=.04) compared with nonresponders. Participants with clinically important changes in systolic BP at 24 weeks had greater metabolic improvements across 52 weeks, compared with those without clinically important systolic BP changes.
本研究的目的是确定在为期52周的生活方式干预中，24周时的反应者（收缩压[BP]至少降低4毫米汞柱）与无反应者相比，代谢危险因素和健康相关生活质量的变化是否更大。参与者（N = 126；年龄，57.4[9.1]岁）在基线以及12、24和52个月时评估了腰围（WC）、静息血压、糖化血红蛋白、血脂和体能。采用36项简式调查问卷评估健康相关生活质量（HRQOL）。在基线时，反应者的心理健康得分（P = 0.04）以及收缩压和舒张压（P < 0.001）均高于无反应者。在52周期间，与无反应者相比，反应者的舒张压（P < 0.001）、腰围（P = 0.01）和最大摄氧量（P = 0.04）也有更大改善。与24周时收缩压无临床显著变化的参与者相比，24周时收缩压有临床显著变化的参与者在52周期间的代谢改善更大。
