食用含益生菌罗伊氏乳杆菌配方奶的足月儿的生长与耐受性
Growth and Tolerance of Term Infants Fed Formula With Probiotic Lactobacillus reuteri.
作者信息
Cekola Pamela L, Czerkies Laura A, Storm Heidi M, Wang Mei H, Roberts James, Saavedra José M
机构信息
Nestlé Nutrition, Florham Park, NJ, USA.
Statistical Consulting, LLC, Portage, MI, USA.
出版信息
Clin Pediatr (Phila). 2015 Oct;54(12):1175-84. doi: 10.1177/0009922815574076. Epub 2015 Mar 10.
BACKGROUND
Lactobacillus reuteri has been studied for its safety and beneficial effects in infants. This study assessed growth of infants fed a partially hydrolyzed whey formula with L reuteri.
METHODS
Healthy term infants were randomized to 1 of 2 formulas (partially hydrolyzed whey formula with (PRO) or without (CON) L reuteri from 14 to 112 days of age. Anthropometric measures were assessed at 14, 28, 56, 84, and 112 days of age. Tolerance records were completed 2 days prior to each visit.
RESULTS
A total of 122 subjects completed study per protocol (60 PRO, 62 CON). No differences were seen in daily weight gain, length, or head circumference. Overall, between groups, there were no significant differences in formula intake, stool frequency, color, consistency, flatulence, frequency of spit-up/vomiting, mood, sleep, or incidence of adverse events.
CONCLUSION
Infants fed probiotic formula had similar growth to infants fed control formula. Both formulas were well tolerated.
背景
已对罗伊氏乳杆菌在婴儿中的安全性和有益作用进行了研究。本研究评估了喂食含罗伊氏乳杆菌的部分水解乳清配方奶粉的婴儿的生长情况。
方法
健康足月儿在14至112日龄时被随机分为两种配方奶粉中的一种（含罗伊氏乳杆菌的部分水解乳清配方奶粉（PRO）或不含罗伊氏乳杆菌的部分水解乳清配方奶粉（CON））。在14、28、56、84和112日龄时评估人体测量指标。每次访视前2天完成耐受性记录。
结果
共有122名受试者按照方案完成了研究（60名PRO组，62名CON组）。每日体重增加、身长或头围未见差异。总体而言，两组之间在配方奶粉摄入量、大便频率、颜色、稠度、肠胃胀气、吐奶/呕吐频率、情绪、睡眠或不良事件发生率方面无显著差异。
结论
喂食益生菌配方奶粉的婴儿与喂食对照配方奶粉的婴儿生长情况相似。两种配方奶粉的耐受性均良好。
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