Institute for Surgical Pathology, University Hospital Zurich, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland.
Virchows Arch. 2011 Nov;459(5):465-75. doi: 10.1007/s00428-011-1151-5. Epub 2011 Oct 14.
Periostin, also called osteoblast-specific factor 2, is a secreted cell adhesion protein, which shares a homology with the insect cell adhesion molecule fasciclin I. It has been shown to be an important regulator of bone and tooth formation and maintenance, and of cardiac development and healing. Recent studies revealed that periostin plays an important role in tumor development and is upregulated in a wide variety of cancers such as colon, pancreatic, ovarian, breast, head and neck, thyroid, and gastric cancer as well as in neuroblastoma. Periostin binding to the integrins activates the Akt/PKB- and FAK-mediated signaling pathways which lead to increased cell survival, angiogenesis, invasion, metastasis, and importantly, epithelial-mesenchymal transition of carcinoma cells. In this review we summarize recent clinicopathological studies that have investigated periostin expression in lung, kidney, prostate, liver cancer, and malignant pleural mesothelioma and discuss the role of periostin isoforms in tumorigenesis and their potential as targets for stroma-targeted anticancer therapy.
骨膜蛋白，又名成骨细胞特异性因子 2，是一种分泌型细胞黏附蛋白，与昆虫细胞黏附分子 fasciclin I 具有同源性。它已被证明是骨和牙齿形成和维持以及心脏发育和修复的重要调节剂。最近的研究表明，骨膜蛋白在肿瘤发展中发挥着重要作用，并在上皮性卵巢癌、乳腺癌、胰腺癌、胃癌、结肠癌、甲状腺癌、神经母细胞瘤等多种癌症中上调。骨膜蛋白与整合素结合，激活 Akt/PKB 和 FAK 介导的信号通路，导致细胞存活、血管生成、侵袭、转移增加，特别是癌细胞的上皮-间充质转化。在这篇综述中，我们总结了最近的临床病理研究，这些研究调查了骨膜蛋白在肺癌、肾癌、前列腺癌、肝癌和恶性胸膜间皮瘤中的表达，并讨论了骨膜蛋白同工型在肿瘤发生中的作用及其作为基质靶向抗癌治疗靶点的潜力。
