Biodynamic Optical Imaging Center (BIOPIC), and College of Engineering, Peking University , Beijing 100871, China.
Biomicrofluidics. 2015 Feb 11;9(1):014118. doi: 10.1063/1.4907982. eCollection 2015 Jan.
We demonstrate a valve-less microfluidic peristaltic pumping method which enables the delivery of continuous nanoliter-scale flow with high precision. The fluid is driven by squeezing the microchannels embedded in a poly(dimethylsiloxane) device with rolling cams or bearings. We achieve continuous and uniform flow with velocity range from 1 to 500 nl/s, with outflow volume error within 3 nl. The devices show enhanced backpressure resistance up to 340 kPa. This method also shows great flexibility. By altering the channels' layout, emulsions and plugs can be generated easily. These low-cost and easy-to-fabricate micro-pumps offer novel approaches for liquid actuation in various microfluidic applications.
我们展示了一种无阀微流控蠕动泵送方法，该方法能够以高精度输送连续的纳升级流量。该方法通过用滚动凸轮或轴承挤压嵌入在聚二甲基硅氧烷装置中的微通道来驱动流体。我们实现了流速范围为 1 至 500nl/s 的连续和均匀流动，流出体积误差小于 3nl。该装置的抗背压能力高达 340kPa。这种方法也具有很大的灵活性。通过改变通道的布局，可以很容易地产生乳液和塞子。这些低成本且易于制造的微泵为各种微流控应用中的液体驱动提供了新的方法。
