无阀微流控蠕动泵送方法。
A valve-less microfluidic peristaltic pumping method.
机构信息
Biodynamic Optical Imaging Center (BIOPIC), and College of Engineering, Peking University , Beijing 100871, China.
出版信息
Biomicrofluidics. 2015 Feb 11;9(1):014118. doi: 10.1063/1.4907982. eCollection 2015 Jan.
Abstract
We demonstrate a valve-less microfluidic peristaltic pumping method which enables the delivery of continuous nanoliter-scale flow with high precision. The fluid is driven by squeezing the microchannels embedded in a poly(dimethylsiloxane) device with rolling cams or bearings. We achieve continuous and uniform flow with velocity range from 1 to 500 nl/s, with outflow volume error within 3 nl. The devices show enhanced backpressure resistance up to 340 kPa. This method also shows great flexibility. By altering the channels' layout, emulsions and plugs can be generated easily. These low-cost and easy-to-fabricate micro-pumps offer novel approaches for liquid actuation in various microfluidic applications.
摘要
我们展示了一种无阀微流控蠕动泵送方法，该方法能够以高精度输送连续的纳升级流量。该方法通过用滚动凸轮或轴承挤压嵌入在聚二甲基硅氧烷装置中的微通道来驱动流体。我们实现了流速范围为 1 至 500nl/s 的连续和均匀流动，流出体积误差小于 3nl。该装置的抗背压能力高达 340kPa。这种方法也具有很大的灵活性。通过改变通道的布局，可以很容易地产生乳液和塞子。这些低成本且易于制造的微泵为各种微流控应用中的液体驱动提供了新的方法。
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Biomicrofluidics. 2013 Jan;7(1):11302. doi: 10.1063/1.4789751. Epub 2013 Jan 31.
2
Commercialization of microfluidic point-of-care diagnostic devices.微流控即时诊断设备的商业化。
Lab Chip. 2012 Jun 21;12(12):2118-34. doi: 10.1039/c2lc21204h. Epub 2012 Feb 17.
3
Openly accessible microfluidic liquid handlers for automated high-throughput nanoliter cell culture.开放式纳升级高通量自动化微流控液体处理系统用于细胞培养
Anal Chem. 2012 Mar 6;84(5):2576-84. doi: 10.1021/ac203469v. Epub 2012 Feb 22.
4
Compressed-air flow control system.压缩空气流量控制系统。
Lab Chip. 2011 Feb 21;11(4):743-7. doi: 10.1039/c0lc00303d. Epub 2010 Nov 29.
5
Multi-channel peristaltic pump for microfluidic applications featuring monolithic PDMS inlay.用于微流控应用的多通道蠕动泵，具有整体式聚二甲基硅氧烷镶嵌件。
Lab Chip. 2009 Oct 21;9(20):3003-6. doi: 10.1039/b906156h. Epub 2009 Jul 17.
6
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