McFarland Marie, Dina Roberto, Fisher Cyril, McCluggage W Glenn
Department of Pathology (M.M. W.G.M.), Belfast Health and Social Care Trust, Belfast, Northern Ireland Department of Pathology (R.D.), Hammersmith Hospital Department of Histopathology (C.F.), Royal Marsden Hospital, London, UK.
Int J Gynecol Pathol. 2015 Jul;34(4):369-73. doi: 10.1097/PGP.0000000000000153.
Mural nodules, which may be benign or malignant, are well recognized in ovarian mucinous neoplasms, especially of borderline type. Malignant mural nodules most commonly comprise anaplastic carcinoma but sarcomas of various types have been reported. We report 2 cases of osteosarcoma occurring in young women (aged 18 and 34) as malignant mural nodules in a Grade 1 ovarian mucinous carcinoma of intestinal type and a borderline mucinous tumor of intestinal type. Primary osteosarcomas of the ovary have been described either arising within a teratoma or as a pure neoplasm but, to the best of our knowledge, osteosarcoma occurring as a mural nodule in an ovarian mucinous neoplasm has not been reported. In both our cases, the tumor was Stage 1 at presentation and the patients were treated with surgery without adjuvant chemotherapy. Both patients are free of disease with follow-up of 12 and 18 mo.
壁结节在卵巢黏液性肿瘤中很常见，可良性或恶性，尤其是交界性肿瘤。恶性壁结节最常见的是间变性癌，但也有各种类型肉瘤的报道。我们报告2例骨肉瘤发生在年轻女性（分别为18岁和34岁），分别为肠型1级卵巢黏液性癌和肠型交界性黏液性肿瘤中的恶性壁结节。卵巢原发性骨肉瘤已被描述为发生于畸胎瘤内或为单纯肿瘤，但据我们所知，骨肉瘤作为卵巢黏液性肿瘤中的壁结节尚未见报道。在我们的2例病例中，肿瘤初诊时均为1期，患者接受了手术治疗，未进行辅助化疗。2例患者随访12个月和18个月均无疾病复发。
