Guo Yanjun, Rong Yi, Huang Xiji, Lai Hanpeng, Luo Xin, Zhang Zhihong, Liu Yuewei, He Meian, Wu Tangchun, Chen Weihong
Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Environment and Health in Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
PLoS One. 2015 Mar 11;10(3):e0120632. doi: 10.1371/journal.pone.0120632. eCollection 2015.
Shift work is indicated to be associated with adverse metabolic disorders. However, potential effects of shift work on metabolic syndrome (MetS) and its components have not been well established.
In total, 26,382 workers from Dongfeng-Tongji Cohort were included in this study. Information on shift work history was gathered through questionnaires and metabolic traits were measured. Logistic regression models were used to calculate the odds ratio (OR) and 95% confidence interval (CI) for long-term shift work related with MetS and each component, respectively. Further stratification analysis was performed to detect the differences on MetS between female and male shift workers.
Long-term shift work was associated with MetS without adjusting for any confounders. Compared with the group of non-shift work, the multivariate-adjusted ORs (95%CI) of MetS associated with 1-10, 11-20, and ≥20y of shift work were 1.05 (0.95-1.16), 1.14 (1.03-1.26), 1.16 (1.01-1.31), respectively. In female workers, we found a dose-response relationship that every 10 years increase in shift work was associated with a 10% (95% CI: 1%-20%) elevated OR of MetS, while no significant dose-response trend was found among male workers. Furthermore, shift work duration was significantly associated with ORs of high blood pressure (1.07, 1.01-1.13), long waist circumference (1.10, 1.01-1.20) and high glucose levels (1.09, 1.04-1.15). No significant association was observed between shift work and low HDL cholesterol) and raised triglyceride levels.
Long-term shift work was associated with metabolic syndrome and the association might differ by gender in retired workers. Applicable intervention strategies are needed for prevention of metabolic disorders for shift workers.
轮班工作被认为与不良代谢紊乱有关。然而，轮班工作对代谢综合征（MetS）及其组成成分的潜在影响尚未完全明确。
本研究共纳入东风-同济队列的26382名工人。通过问卷调查收集轮班工作史信息，并测量代谢特征。采用逻辑回归模型分别计算与MetS及其各组成成分相关的长期轮班工作的比值比（OR）和95%置信区间（CI）。进行进一步分层分析以检测男女轮班工人在MetS方面的差异。
在未调整任何混杂因素的情况下，长期轮班工作与MetS相关。与非轮班工作组相比，轮班工作1 - 10年、11 - 20年和≥20年的MetS多变量调整OR（95%CI）分别为1.05（0.95 - 1.16）、1.14（1.03 - 1.26）、1.16（1.01 - 1.31）。在女性工人中，我们发现了剂量反应关系，即轮班工作每增加10年，MetS的OR升高10%（95%CI：1% - 20%），而在男性工人中未发现显著的剂量反应趋势。此外，轮班工作时长与高血压（1.07，1.01 - 1.13）、腰围过长（1.10，1.01 - 1.20）和血糖水平升高（1.09，1.04 - 1.15）的OR显著相关。未观察到轮班工作与低高密度脂蛋白胆固醇及甘油三酯水平升高之间存在显著关联。
长期轮班工作与代谢综合征相关，且这种关联在退休工人中可能因性别而异。需要采取适用的干预策略来预防轮班工人的代谢紊乱。
