Department of Psychiatry, University of Pittsburgh, Western Psychiatric Hospital, 3811 O'Hara Street, Pittsburgh, PA, 15213, USA.
Department of Psychology, Trinity College, Hartford, CT, 06106, USA.
Sci Rep. 2023 Mar 30;13(1):5204. doi: 10.1038/s41598-022-20743-1.
Night shift work is associated with poor cardiometabolic outcomes, even post-retirement. However, the characteristics of cardiometabolic function in retired night shift workers (RNSW) compared to retired day workers (RDW) are not well-understood. Rigorous characterization of cardiometabolic dysfunction in RNSW and RDW will inform targeted risk stratification for RNSW. This observational study evaluated whether RNSW (n = 71) had poorer cardiometabolic function than RDW (n = 83). We conducted a multimodal assessment of cardiometabolic function including metabolic syndrome prevalence, brachial artery flow-mediated dilation, and carotid intima-media thickness. Main analyses tested overall group differences. Sex-stratified follow-up analyses tested group differences separately in men and women. RNSW had 2.6-times higher odds of metabolic syndrome prevalence than RDW in unadjusted analyses (95% CI [1.1,6.3]); this association was not significant when adjusting for age, race and education. RNSW and RDW (M = 68.4; 55% female) did not differ in percent flow-mediated dilation or carotid intima-media thickness. In sex-stratified analyses, women RNSW had 3.3-times higher odds of having high body mass index than women RDW (95% CI [1.2,10.4]). Men RNSW had 3.9-times higher odds of having high triglycerides than men RDW (95% CI [1.1,14.2]). No other group differences were observed. We found mixed evidence that night shift work exposure was associated with cardiometabolic dysfunction in retirement, possibly in a sex-specific manner.
夜班工作与较差的心血代谢结果相关，即使是退休后也是如此。然而，与退休白班工人（RDW）相比，退休夜班工人（RNSW）的心血代谢功能特征尚未得到充分了解。对 RNSW 的心血代谢功能障碍进行严格的特征描述将为 RNSW 提供有针对性的风险分层。本观察性研究评估了 RNSW（n=71）的心血代谢功能是否比 RDW（n=83）差。我们对心血代谢功能进行了多模态评估，包括代谢综合征患病率、肱动脉血流介导的扩张和颈动脉内膜中层厚度。主要分析测试了总体组间差异。性别分层随访分析分别测试了男性和女性组间的差异。未经调整的分析中，RNSW 患代谢综合征的几率比 RDW 高 2.6 倍（95%CI [1.1,6.3]）；当调整年龄、种族和教育时，这种关联并不显著。RNSW 和 RDW（M=68.4；55%为女性）在血流介导的扩张百分比或颈动脉内膜中层厚度方面没有差异。在性别分层分析中，女性 RNSW 患高体重指数的几率比女性 RDW 高 3.3 倍（95%CI [1.2,10.4]）。男性 RNSW 患高甘油三酯的几率比男性 RDW 高 3.9 倍（95%CI [1.1,14.2]）。没有观察到其他组间差异。我们发现有混合证据表明夜班工作暴露与退休后的心血代谢功能障碍有关，可能存在性别特异性。
