Dhar Purbarun, Bhattacharya Soumya, Nayar Suprabha, Das Sarit K
†Department of Mechanical Engineering, Indian Institute of Technology, Madras, Chennai - 600 036, India.
‡Biomaterials Group, Materials Science and Technology Division, National Metallurgical Laboratory (CSIR), Jamshedpur - 831 007, India.
Langmuir. 2015 Mar 31;31(12):3696-706. doi: 10.1021/acs.langmuir.5b00067. Epub 2015 Mar 17.
Collagen microfibrils biomimetically intercalate graphitic structures in aqueous media to form graphene nanoplatelet-collagen complexes (G-Cl). Synthesized G-Cl-based stable, aqueous bionanocolloids exhibit anomalously augmented charge transportation capabilities oversimple collagen or graphene based colloids. The concentration tunable electrical transport properties of synthesized aqueous G-Cl bionanocolloids has been experimentally observed, theoretically analyzed, and mathematically modeled. A comprehensive approach to mathematically predict the electrical transport properties of simple graphene and collagen based colloids has been presented. A theoretical formulation to explain the augmented transport characteristics of the G-Cl bionanocolloids based on the physicochemical interactions among the two entities, as revealed from extensive characterizations of the G-Cl biocomplex, has also been proposed. Physical interactions between the zwitterionic amino acid molecules within the collagen triple helix with the polar water molecules and the delocalized π electrons of graphene and subsequent formation of partially charged entities has been found to be the crux mechanism behind the augmented transport phenomena. The analysis has been observed to accurately predict the degree of enhancement in transport of the concentration tunable composite colloids over the base colloids. The electrically active G-Cl bionanocolloids with concentration tunability promises find dual utility in novel gel bioelectrophoresis-based protein separation techniques and advanced surface charge modulated drug delivery using biocolloids.
