Spagnolo Primavera A, Colloca Luana, Heilig Markus
Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA
Pain and Translational Symptom Science, School of Nursing, University of Maryland Baltimore, Baltimore, MD, USA UM Center to Advance Chronic Pain Research, University of Maryland Baltimore, Baltimore, MD, USA Department of Anesthesiology, School of Medicine, University of Maryland Baltimore, Baltimore, MD, USA.
Alcohol Alcohol. 2015 May;50(3):282-5. doi: 10.1093/alcalc/agv015. Epub 2015 Mar 11.
Throughout history, patient-physician relationships have been acknowledged as an important component of the therapeutic effects of any pharmacological treatment. Here, we discuss the role of physicians' expectations in influencing the therapeutic outcomes of alcohol and drug addiction pharmacological treatments. As largely demonstrated, such expectations and attitudes may contribute to produce placebo and nocebo effects that in turn affect the course of the disease and the response to the therapy. This article is aimed at discussing the current insights into expectations, placebo and nocebo mechanisms and their impact on the therapeutic outcomes of alcohol and drug addiction treatments; with the goal of informing physicians and other health care providers about the potentially widespread implications for clinical practice and for a successful treatment regimen.
纵观历史，医患关系一直被视为任何药物治疗疗效的重要组成部分。在此，我们探讨医生的期望在影响酒精和药物成瘾药物治疗疗效方面的作用。大量研究表明，这种期望和态度可能会产生安慰剂和反安慰剂效应，进而影响疾病进程和对治疗的反应。本文旨在讨论当前对期望、安慰剂和反安慰剂机制及其对酒精和药物成瘾治疗疗效影响的见解；目的是让医生和其他医疗服务提供者了解其对临床实践和成功治疗方案可能产生的广泛影响。
