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用于心脏再生的重编程。

Reprogramming for cardiac regeneration.

作者信息

Raynaud Christophe Michel, Ahmad Faizzan Syed, Allouba Mona, Abou-Saleh Haissam, Lui Kathy O, Yacoub Magdi

机构信息

Qatar Cardiovascular Research Center, Qatar Foundation-Education City, Doha, Qatar.

Aswan Heart Center, Magdi Yacoub Foundation, Aswan, Egypt.

出版信息

Glob Cardiol Sci Pract. 2014 Oct 16;2014(3):309-29. doi: 10.5339/gcsp.2014.44. eCollection 2014.

DOI:10.5339/gcsp.2014.44
PMID:25763379
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4352683/
Abstract

Treatment of cardiovascular diseases remains challenging considering the limited regeneration capacity of the heart muscle. Developments of reprogramming strategies to create in vitro and in vivo cardiomyocytes have been the focus point of a considerable amount of research in the past decades. The choice of cells to employ, the state-of-the-art methods for different reprogramming strategies, and their promises and future challenges before clinical entry, are all discussed here.

摘要

考虑到心肌的再生能力有限，心血管疾病的治疗仍然具有挑战性。在过去几十年中，开发用于在体外和体内生成心肌细胞的重编程策略一直是大量研究的重点。本文将讨论用于重编程的细胞选择、不同重编程策略的最新方法，以及它们在进入临床之前的前景和未来挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aec2/4352683/14f35c6973ad/gcsp-2014-044-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aec2/4352683/fae61924c744/gcsp-2014-044-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aec2/4352683/1c48d23f57ba/gcsp-2014-044-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aec2/4352683/022d3d7064ad/gcsp-2014-044-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aec2/4352683/a52fd3c69996/gcsp-2014-044-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aec2/4352683/87200bf4361f/gcsp-2014-044-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aec2/4352683/1eed8562c046/gcsp-2014-044-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aec2/4352683/14f35c6973ad/gcsp-2014-044-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aec2/4352683/fae61924c744/gcsp-2014-044-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aec2/4352683/1c48d23f57ba/gcsp-2014-044-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aec2/4352683/022d3d7064ad/gcsp-2014-044-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aec2/4352683/a52fd3c69996/gcsp-2014-044-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aec2/4352683/87200bf4361f/gcsp-2014-044-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aec2/4352683/1eed8562c046/gcsp-2014-044-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aec2/4352683/14f35c6973ad/gcsp-2014-044-g007.jpg

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本文引用的文献

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Organogenesis in a dish: modeling development and disease using organoid technologies.器官发生在培养皿中：使用类器官技术模拟发育和疾病。
Science. 2014 Jul 18;345(6194):1247125. doi: 10.1126/science.1247125. Epub 2014 Jul 17.
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Reprogramming human endothelial cells to haematopoietic cells requires vascular induction.将人类内皮细胞重编程为造血细胞需要血管诱导。
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Identification and purification of human induced pluripotent stem cell-derived atrial-like cardiomyocytes based on sarcolipin expression.
基于肌浆蛋白表达对人诱导多能干细胞来源的心房样心肌细胞进行鉴定和纯化。
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Abnormalities in human pluripotent cells due to reprogramming mechanisms.人多能细胞因重编程机制而出现的异常。
Nature. 2014 Jul 10;511(7508):177-83. doi: 10.1038/nature13551. Epub 2014 Jul 2.
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Stem cells: The quest for the perfect reprogrammed cell.干细胞：对完美重编程细胞的探索。
Nature. 2014 Jul 10;511(7508):160-2. doi: 10.1038/nature13515. Epub 2014 Jul 2.
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Endothelial cells contribute to generation of adult ventricular myocytes during cardiac homeostasis.在心脏稳态过程中，内皮细胞有助于成年心室肌细胞的生成。
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Allele-specific genome editing and correction of disease-associated phenotypes in rats using the CRISPR-Cas platform.利用CRISPR-Cas平台在大鼠中进行等位基因特异性基因组编辑及纠正疾病相关表型
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An iCRISPR platform for rapid, multiplexable, and inducible genome editing in human pluripotent stem cells.一种用于在人类多能干细胞中进行快速、多重且可诱导的基因组编辑的iCRISPR平台。
Cell Stem Cell. 2014 Aug 7;15(2):215-226. doi: 10.1016/j.stem.2014.05.018. Epub 2014 Jun 12.
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Targeted inversion and reversion of the blood coagulation factor 8 gene in human iPS cells using TALENs.利用 TALEN 技术靶向敲入和敲除人诱导多能干细胞中的凝血因子 8 基因。
Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9253-8. doi: 10.1073/pnas.1323941111. Epub 2014 Jun 9.
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Transplanted terminally differentiated induced pluripotent stem cells are accepted by immune mechanisms similar to self-tolerance.移植的终末分化诱导多能干细胞被类似于自身耐受的免疫机制所接受。
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