Liu Jun, Li Weihui, Zhou Shunke, Zhang Li, Wang Zhiyuan, Zhang Yan, Jiang Yebin, Li Lingjiang
Department of Radiology, Second Xiangya Hosipital, Central South University, Changsha, 410011, Hunan Province, China.
School of Public Administration, Central South University, Changsha, 410083, Hunan Province, China.
Brain Imaging Behav. 2016 Mar;10(1):60-7. doi: 10.1007/s11682-015-9364-x.
Internet gaming disorder (IGD) is a subtype of internet addiction disorder (IAD), but its pathogenesis remains unclear. This study investigated brain function in IGD individuals using task-state functional magnetic resonance imaging (fMRI). It is a prospective study in 19 IGD individuals and 19 matched healthy controls. They all received internet videogame stimuli while a 3.0 T fMRI was used to assess echo planar imaging. Brain activity was analyzed using the Brain Voyager software package. Functional data were spatially smoothed using Gaussian kernel. The threshold level was positioned at 10 pixels, and the activation range threshold was set to 10 voxels. Activated brain regions were compared between the two groups, as well as the amount of activated voxels. The internet videogame stimuli activated brain regions in both groups. Compared with controls, the IGD group showed increased activation in the right superior parietal lobule, right insular lobe, right precuneus, right cingulated gyrus, right superior temporal gyrus, and left brainstem. There was a significant difference in the number of activated voxels between the two groups. An average of 1078 voxels was activated in the IGD group compared with only 232 in the control group. Internet videogame play activates the vision, space, attention, and execution centers located in the occipital, temporal, parietal, and frontal gyri. Abnormal brain function was noted in IGD subjects, with hypofunction of the frontal cortex. IGD subjects showed laterality activation of the right cerebral hemisphere.
网络游戏障碍（IGD）是网络成瘾障碍（IAD）的一种亚型，但其发病机制仍不清楚。本研究使用任务态功能磁共振成像（fMRI）对IGD个体的脑功能进行了调查。这是一项针对19名IGD个体和19名匹配的健康对照的前瞻性研究。他们在接受互联网视频游戏刺激时，使用3.0T fMRI评估回波平面成像。使用Brain Voyager软件包分析脑活动。功能数据使用高斯核进行空间平滑。阈值水平设定为10像素，激活范围阈值设定为10体素。比较两组之间激活的脑区以及激活体素的数量。互联网视频游戏刺激在两组中均激活了脑区。与对照组相比，IGD组在右侧顶上小叶、右侧岛叶、右侧楔前叶、右侧扣带回、右侧颞上回和左侧脑干的激活增加。两组之间激活体素的数量存在显著差异。IGD组平均激活1078个体素，而对照组仅激活232个。互联网视频游戏激活了位于枕叶、颞叶、顶叶和额叶回的视觉、空间、注意力和执行中枢。IGD受试者存在脑功能异常，额叶皮质功能减退。IGD受试者表现出右侧大脑半球的偏侧激活。
