BIOMED, School of Life Sciences, Hasselt University, 3590 Diepenbeek, Belgium.
REVAL Rehabilitation Research Center, BIOMED Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, 3590 Diepenbeek, Belgium.
Int J Mol Sci. 2018 Jan 8;19(1):193. doi: 10.3390/ijms19010193.
Multiple sclerosis (MS) is an inflammatory auto-immune disease of the central nervous system (CNS). Serum glucose alterations and impaired glucose tolerance (IGT) are reported in MS patients, and are commonly associated with the development of cardio-metabolic co-morbidities. We previously found that a subgroup of MS patients shows alterations in their lipoprotein profile that are similar to a pre-cardiovascular risk profile. In addition, we showed that a high-intensity exercise training has a positive effect on IGT in MS patients. In this study, we hypothesize that exercise training positively influences the lipoprotein profile of MS patients. To this end, we performed a pilot study and determined the lipoprotein profile before (controls, = 40; MS patients, = 41) and after ( = 41 MS only) 12 weeks of medium-intensity continuous training (MIT, = 21, ~60% of VO) or high-intensity interval training (HIT, = 20, ~100-200% of VO) using nuclear magnetic resonance spectroscopy (NMR). Twelve weeks of MIT reduced intermediate-density lipoprotein particle count ((nmol/L); -43.4%; < 0.01), low-density lipoprotein cholesterol (LDL-c (mg/dL); -7.6%; < 0.05) and VLDL size ((nm); -6.6%; < 0.05), whereas HIT did not influence the lipoprotein profile. These results show that MIT partially normalizes lipoprotein alterations in MS patients. Future studies including larger patient and control groups should determine whether MIT can reverse other lipoprotein levels and function and if these alterations are related to MS disease progression and the development of co-morbidities.
多发性硬化症（MS）是一种中枢神经系统（CNS）的炎症性自身免疫性疾病。MS 患者的血清葡萄糖改变和葡萄糖耐量受损（IGT）已有报道，并且通常与心血管代谢合并症的发生有关。我们之前发现，MS 患者的脂蛋白谱发生改变，类似于心血管风险前的特征。此外，我们还发现高强度运动训练对 MS 患者的 IGT 有积极影响。在这项研究中，我们假设运动训练对 MS 患者的脂蛋白谱有积极影响。为此，我们进行了一项初步研究，在运动训练前（对照组，n = 40；MS 患者，n = 41）和运动训练后（MS 患者，n = 41），使用核磁共振波谱法（NMR）测定脂蛋白谱，运动训练持续 12 周，采用中等强度连续训练（MIT，n = 21，60%的 VO ）或高强度间歇训练（HIT，n = 20，100-200%的 VO ）。MIT 持续 12 周可降低中间密度脂蛋白颗粒数（nmol/L；-43.4%；<0.01）、低密度脂蛋白胆固醇（LDL-c（mg/dL）；-7.6%；<0.05）和 VLDL 大小（nm；-6.6%；<0.05），而 HIT 对脂蛋白谱没有影响。这些结果表明，MIT 可部分纠正 MS 患者的脂蛋白异常。未来包括更大的患者和对照组的研究应确定 MIT 是否可以逆转其他脂蛋白水平和功能，以及这些变化是否与 MS 疾病进展和合并症的发生有关。
