Gröber Uwe, Reichrath Jörg, Holick Michael F
Academy for Micronutrient Medicine, Zweigertstr, 55, 45130 Essen, Germany.
Department of Dermatology, The Saarland University Hospital, 66421 Homburg/Saar, Germany.
Nutrients. 2015 Mar 12;7(3):1871-80. doi: 10.3390/nu7031871.
The global burden of vitamin D deficiency or insufficiency is of great concern for public health. According to recent studies, vitamin D deficiency is an important etiological factor in the pathogenesis of many chronic diseases. Whether or not there is a connection between 25-hydoxyvitamin D (25(OH)D) status and overall mortality is a matter of considerable debate. A new meta-analysis confirmed that low 25(OH)D levels were associated with a significant increased risk for all-cause mortality. Individuals with severe vitamin D deficiency have almost twice the mortality rate as those with 25(OH)D level ≥ 30 ng/mL, (≥75 nmol/L). Unlike previous meta-analyses which suggested that serum 25(OH)D > 50 ng/mL was associated with increased mortality, this new analysis found that there was no increased risk even when 25(OH)D levels were ≥70 ng/mL. In general, closer attention should be paid to vitamin D deficiency in medical and pharmaceutical practice than has been the case hitherto. The results of these studies are consistent with the recommendation to improve the general vitamin D status in children and adults by means of a healthy approach to sunlight exposure, consumption of foods containing vitamin D and supplementation with vitamin D preparations.
维生素D缺乏或不足的全球负担是公共卫生领域极为关注的问题。根据最近的研究，维生素D缺乏是许多慢性疾病发病机制中的一个重要病因。25-羟基维生素D（25(OH)D）水平与全因死亡率之间是否存在关联是一个备受争议的问题。一项新的荟萃分析证实，低25(OH)D水平与全因死亡率显著增加的风险相关。严重维生素D缺乏的个体死亡率几乎是25(OH)D水平≥30 ng/mL（≥75 nmol/L）者的两倍。与之前表明血清25(OH)D>50 ng/mL与死亡率增加相关的荟萃分析不同，这项新分析发现，即使25(OH)D水平≥70 ng/mL，也没有增加的风险。总体而言，在医疗和制药实践中，应比以往更加关注维生素D缺乏问题。这些研究结果与通过健康的阳光照射方式、食用含维生素D的食物以及补充维生素D制剂来改善儿童和成人总体维生素D状况的建议一致。
