Liang Xian-Ting, Wang Yan-Yan, Hu Xiao-Yu, Wang Shao-Bo
Department of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, China.
Department of Infectious Diseases, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, China.
Evid Based Complement Alternat Med. 2021 Jan 13;2021:6641919. doi: 10.1155/2021/6641919. eCollection 2021.
Acute alcoholism (AAI) is a common emergency. Currently, there is a lack of preventive and therapeutic drugs with superior safety and efficacy. , , , flower, and Thunb., which are the components of compound turmeric recipe (CTR), are, respectively, used in China as adjuvant therapeutic agents for AAI and alcoholic liver injury, respectively. The purpose of this research was to investigate the effect of traditional compound turmeric recipe in anti-inebriation treatment and to identify its underlying mechanisms. The mice were administered with CTR mixture, and ethanol was subsequently given to mice by gavage. The effects of CTR on the righting reflex, 24-hour survival, drunken behavior, blood ethanol concentration, and pathological changes of liver are depicted. The activities of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) were detected. Besides, the activities of tumor necrosis factor- (TNF-), interleukin-8 (IL-8), alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), cytochrome P450 (P450), superoxide dismutase (SOD), and malondialdehyde (MDA) in the liver and the levels of -endorphin (-EP) and leucine enkephalin (LENK) in the brain were also measured. Our results demonstrated that CTR can increase the activities of ADH, ALDH, P450, and SOD and decrease the contents of TNF-, IL-8, and MDA in the liver. In addition, it can decrease the activities of ALT, AST, and ALP in serum and -EP and LENK activities in the brain. CTR showed effects on prevention of acute alcoholism, promoting wakefulness, and alleviating alcoholic liver injury, which were likely mediated by the above mechanisms.
急性酒精中毒（AAI）是一种常见的急症。目前，缺乏具有卓越安全性和疗效的预防和治疗药物。 、 、 花以及 ，它们是复方姜黄配方（CTR）的成分，在中国分别用作AAI和酒精性肝损伤的辅助治疗药物。本研究的目的是探讨传统复方姜黄配方在解酒治疗中的作用，并确定其潜在机制。给小鼠灌胃CTR混合物，随后通过灌胃给予小鼠乙醇。描述了CTR对翻正反射、24小时存活率、醉酒行为、血液乙醇浓度和肝脏病理变化的影响。检测了血清丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）和碱性磷酸酶（ALP）的活性。此外，还测量了肝脏中肿瘤坏死因子-（TNF-）、白细胞介素-8（IL-8）、乙醇脱氢酶（ADH）、乙醛脱氢酶（ALDH）、细胞色素P450（P450）、超氧化物歧化酶（SOD）和丙二醛（MDA）的活性以及脑中β-内啡肽（β-EP）和亮氨酸脑啡肽（LENK）的水平。我们的结果表明，CTR可以增加肝脏中ADH、ALDH、P450和SOD的活性，降低TNF-、IL-8和MDA的含量。此外，它可以降低血清中ALT、AST和ALP的活性以及脑中β-EP和LENK的活性。CTR对预防急性酒精中毒、促进清醒和减轻酒精性肝损伤有作用，这些作用可能是由上述机制介导的。
