Du Yong, Sanam Soomro, Kate Krause, Mohan Chandra
Department of Biomedical Engineering, University of Houston, 3605 Cullen Blvd, Room 2018, Houston, TX - 77204, USA.
Curr Pharm Des. 2015;21(18):2320-49. doi: 10.2174/1381612821666150316115727.
This article reviews the commonly used murine strains for studying lupus and lupus nephritis, including strains that develop lupus spontaneously, congenic strains, induced models of lupus, as well as genetically engineered mouse models of lupus bearing transgenes or knockouts. The review then summarizes the main cellular and molecular pathways that lead to the pathogenesis of this autoimmune disease, including autoantibodies. Finally, it concludes with therapeutic insights gained from using mouse models of lupus. To sum, much of what we have learned about lupus has arisen from studying mouse models of the disease, and the laboratory mouse continues to be one of the best tools for studying human SLE.
本文综述了用于研究狼疮和狼疮性肾炎的常用小鼠品系，包括自发发生狼疮的品系、同源近交系、狼疮诱导模型，以及携带转基因或基因敲除的狼疮基因工程小鼠模型。该综述接着总结了导致这种自身免疫性疾病发病机制的主要细胞和分子途径，包括自身抗体。最后，它总结了从使用狼疮小鼠模型中获得的治疗见解。总之，我们对狼疮的许多了解都来自对该疾病小鼠模型的研究，而实验室小鼠仍然是研究人类系统性红斑狼疮的最佳工具之一。
