Sun Huiling, Deng Qiwen, Pan Yuqin, He Bangshun, Ying Houqun, Chen Jie, Liu Xian, Wang Shukui
Department of Life Sciences, Nanjing Normal University, Nanjing, China.
J BUON. 2015 Jan-Feb;20(1):296-308.
Emerging published reports on the association between estrogen receptor 1 (ESR1) genetic variation and cancer susceptibility are inconsistent. This review and meta- analysis was performed to achieve a more precise evaluation of this relationship.
A literature search of PubMed database was conducted from the inception of this study through April 1st 2014. Crude odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated to assess the association.
87 studies were enrolled in this meta-analysis. The results indicated that PvuII (T>C) polymorphism was associated with an increased risk of hepatocellular carcinoma (HCC) and prostate cancer, in contrast with the decreased risk of gallbladder cancer. No significant association was found in Asian and Caucasian populations. Furthermore, XbaI (A>G) genetic variation was only associated with an increased risk of prostate cancer, but was not related with race. In addition, T594T (G>A) polymorphisms were significantly associated with an increased risk of cancer, especially in Asian populations.
This meta-analysis indicated that PvuII (T>C) genetic variation may be risk factor for HCC, prostate cancer and gallbladder cancer. Meanwhile, XbaI (A>G) polymorphism may be potential prognostic factor for prostate cancer. Furthermore, T594T (G>A) was closely related with cancer susceptibility, especially in Asian populations.
关于雌激素受体1（ESR1）基因变异与癌症易感性之间关联的已发表报告并不一致。本综述和荟萃分析旨在对这种关系进行更精确的评估。
从本研究开始至2014年4月1日对PubMed数据库进行文献检索。计算粗比值比（OR）及95%置信区间（95%CI）以评估关联性。
本荟萃分析纳入了87项研究。结果表明，PvuII（T>C）多态性与肝细胞癌（HCC）和前列腺癌风险增加相关，与胆囊癌风险降低相反。在亚洲和白种人群中未发现显著关联。此外，XbaI（A>G）基因变异仅与前列腺癌风险增加相关，与种族无关。另外，T594T（G>A）多态性与癌症风险增加显著相关，尤其是在亚洲人群中。
本荟萃分析表明，PvuII（T>C）基因变异可能是HCC、前列腺癌和胆囊癌的危险因素。同时，XbaI（A>G）多态性可能是前列腺癌的潜在预后因素。此外，T594T（G>A）与癌症易感性密切相关，尤其是在亚洲人群中。
