生活方式和环境措施在原发性肝细胞癌的一级预防中的作用。
Lifestyle and Environmental Approaches for the Primary Prevention of Hepatocellular Carcinoma.
机构信息
Division of Gastroenterology, GRJ-825C, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA; Harvard Medical School, Boston, MA, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, USA.
Division of Gastroenterology, GRJ-825C, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA; Harvard Medical School, Boston, MA, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Broad Institute, Boston, MA, USA; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
出版信息
Clin Liver Dis. 2020 Nov;24(4):549-576. doi: 10.1016/j.cld.2020.06.002. Epub 2020 Aug 25.
Patients with chronic liver disease are at increased risk of developing hepatocellular carcinoma (HCC). Most patients diagnosed with HCC have limited treatment options and a poor overall prognosis, with a 5-year survival less than 15%. Preventing the development of HCC represents the most important strategy. However, current guidelines lack specific recommendations for primary prevention. Lifestyle factors may be central in the pathogenesis of HCC, and primary prevention strategies focused on lifestyle modification could represent an important approach to the prevention of HCC. Both experimental and epidemiologic studies have identified promising chemopreventive agents for the primary prevention of HCC.
患有慢性肝脏疾病的患者发生肝细胞癌 (HCC) 的风险增加。大多数被诊断患有 HCC 的患者的治疗选择有限，总体预后较差，5 年生存率低于 15%。预防 HCC 的发生是最重要的策略。然而，目前的指南缺乏针对初级预防的具体建议。生活方式因素可能在 HCC 的发病机制中起核心作用，侧重于生活方式改变的初级预防策略可能是预防 HCC 的重要方法。实验和流行病学研究已经确定了一些有前途的化学预防药物，可用于 HCC 的初级预防。
Zotero 插件