Lyu Jeonghyeon, Kim Byung-Joo, Kim Hyungwoo
Division of Pharmacology, Pusan National University School of Korean Medicine, Yangsan, Korea.
Division of Longevity and Biofunctional Medicine, Pusan National University School of Korean Medicine, Yangsan, Korea.
J Pharmacopuncture. 2013 Jun;16(2):41-5. doi: 10.3831/KPI.2013.16.013.
The root bark of Ulmus davidiana var. Japonica (Ulmi Radicis cortex, URC) is a medicinal herb used for promoting diuresis and treating dampness. In Korea, URC has long been used as an efficacious therapy for inflammation, burns, frostbite and skin diseases such as eczema and psoriasis.
In the present study, we used 1-fluoro-2,4- dinitrofluorobenzene (DNFB)-induced contact dermatitis (CD) mouse model to investigate the antiallergic and the anti-inflammatory effects of URC on skin lesion, histopathological changes and specific antibody production.
URC treatment, 10 mg/mL, effectively inhibited skin lesions induced by repeated paintings with DNFB. In the histopathological observation, topical application of URC inhibited spongiosis. In addition, URC lowered the production levels of total immunoglobulin and IgG2a in serum.
These data indicate that URC has an anti-inflammatory effect that produces an improvement of skin lesions in CD mice.
大果榆根皮是一种用于利尿和祛湿的草药。在韩国，大果榆根皮长期以来一直被用作治疗炎症、烧伤、冻伤以及湿疹和牛皮癣等皮肤病的有效疗法。
在本研究中，我们使用1-氟-2,4-二硝基氟苯（DNFB）诱导的接触性皮炎（CD）小鼠模型，来研究大果榆根皮对皮肤损伤、组织病理学变化和特异性抗体产生的抗过敏和抗炎作用。
10mg/mL的大果榆根皮处理有效抑制了反复涂抹DNFB诱导的皮肤损伤。在组织病理学观察中，局部应用大果榆根皮可抑制海绵形成。此外，大果榆根皮降低了血清中总免疫球蛋白和IgG2a的产生水平。
这些数据表明，大果榆根皮具有抗炎作用，可改善CD小鼠的皮肤损伤。
