Albu Silviu, Trombitas Veronica, Vlad Diana, Emanuelli Enzo
IInd Department of Otolaryngology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Department of Otorhinolaryngology and Otologic Surgery, Azienda Ospedaliera, Policlinico of Padua, University of Padua, Padua, Italy.
Laryngoscope. 2016 Jan;126(1):25-32. doi: 10.1002/lary.25257. Epub 2015 Mar 17.
OBJECTIVES/HYPOTHESIS: The aim of this study was to assess the influence of spray cryotherapy on wound healing following endoscopic sinus surgery (ESS).
A prospective, randomized, double-blinded, controlled trial.
The study included 22 consecutive adult patients with chronic rhinosinusitis with and without polyps scheduled for bilateral ESS. At the end of the surgical procedure, patients were randomized to the distribution of spray cryotherapy in one middle meatus and saline contralaterally. Outcomes were only measured for endoscopy scores. Thus, postoperative healing and the amount of edema, crusting, secretions, and scarring were assessed using the validated Lund-Kennedy and Perioperative Sinus Endoscopy (POSE) scores.
There were no baseline differences concerning POSE and Lund-Kennedy scores between the two groups. Nevertheless, a significant difference was recorded at one, 2, 4, 8, and 12 weeks in both POSE (P = .001, P = .012, P = .02, P = .006, P = .001) and Lund-Kennedy (P = .002, P = .005, P = .02, P = .02, P = .03) scores.
These preliminary results reveal an improvement in postoperative scores, demonstrating enhanced healing following spray cryotherapy. However, without patient subjective outcomes, the study is limited. Additional studies with longer follow-up and larger samples are needed to describe the effects of cryotherapy on wound healing.
目的/假设：本研究旨在评估喷雾冷冻疗法对鼻内镜鼻窦手术（ESS）后伤口愈合的影响。
一项前瞻性、随机、双盲、对照试验。
该研究纳入了22例连续的成年慢性鼻窦炎患者，这些患者均计划接受双侧ESS，部分伴有鼻息肉，部分不伴有鼻息肉。在手术结束时，患者被随机分配，一侧中鼻道接受喷雾冷冻疗法，另一侧接受生理盐水处理。仅通过内镜评分来衡量结果。因此，使用经过验证的Lund-Kennedy和围手术期鼻窦内镜检查（POSE）评分来评估术后愈合情况以及水肿、结痂、分泌物和瘢痕形成的程度。
两组之间在POSE和Lund-Kennedy评分方面没有基线差异。然而，在第1、2、4、8和12周时，POSE评分（P = .001，P = .012，P = .02，P = .006，P = .001）和Lund-Kennedy评分（P = .002，P = .005，P = .02，P = .02，P = .03）均出现了显著差异。
这些初步结果显示术后评分有所改善，表明喷雾冷冻疗法可促进愈合。然而，由于缺乏患者的主观结果，该研究存在局限性。需要进行更多随访时间更长、样本量更大的研究来描述冷冻疗法对伤口愈合的影响。
