蛋白质设计：过去、现在与未来。
Protein design: Past, present, and future.
作者信息
Regan Lynne, Caballero Diego, Hinrichsen Michael R, Virrueta Alejandro, Williams Danielle M, O'Hern Corey S
机构信息
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT.
Department of Chemistry, Yale University, New Haven, CT.
出版信息
Biopolymers. 2015 Jul;104(4):334-50. doi: 10.1002/bip.22639.
Abstract
Building on the pioneering work of Ho and DeGrado (J Am Chem Soc 1987, 109, 6751-6758) in the late 1980s, protein design approaches have revealed many fundamental features of protein structure and stability. We are now in the era that the early work presaged - the design of new proteins with practical applications and uses. Here we briefly survey some past milestones in protein design, in addition to highlighting recent progress and future aspirations.
摘要
基于20世纪80年代后期何（Ho）和德格拉多（DeGrado）的开创性工作（《美国化学会志》，1987年，第109卷，6751 - 6758页），蛋白质设计方法揭示了蛋白质结构和稳定性的许多基本特征。我们现在正处于早期工作所预示的时代——设计具有实际应用和用途的新型蛋白质。在此，我们除了强调近期进展和未来期望外，还简要回顾了蛋白质设计领域过去的一些里程碑事件。
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