Lopes Maria Luiza Diniz de Sousa, Albuquerque Assis Filipe Medeiros, Germano Adriano Rocha, Queiroz Lélia Maria Guedes, Miguel Márcia Cristina da Costa, da Silveira Éricka Janine Dantas
Postgraduate Program in Oral Pathology, Dentistry Department, Federal University of Rio Grande do Norte, Avenida Salgado Filho, 1787-Lagoa Nova, Natal, RN, CEP 59.056-000, Brazil,
Oral Maxillofac Surg. 2015 Sep;19(3):321-7. doi: 10.1007/s10006-015-0490-9. Epub 2015 Mar 19.
Renal osteodystrophy (ROD) is the bone pathology that occurs as an uncommon complication related to the several alterations in mineral metabolism present in patients with chronic kidney disease (CKD). This paper describes two cases of severe ROD affecting the maxilla and mandible and causing facial disfigurement of a young and a middle-aged female patient with CKD. Both patients had a history of secondary hyperparathyroidism, previously treated by surgery. The pathogenesis of the disease, as well as its clinical, imaging, and histopathological features, and management of the patient are discussed.
肾性骨营养不良（ROD）是一种骨病理状态，作为一种罕见的并发症，它与慢性肾脏病（CKD）患者矿物质代谢的多种改变相关。本文描述了两例严重ROD病例，分别影响一名年轻女性和一名中年女性CKD患者的上颌骨和下颌骨，并导致面部畸形。两名患者均有继发性甲状旁腺功能亢进病史，此前已接受手术治疗。文中讨论了该疾病的发病机制、临床、影像学和组织病理学特征以及患者的治疗方法。
