Wu Xinhua, Liu Huanbo
Department of Internal Medicine, The 425th Hospital of PLA Sanya 572000, Hainan, China.
Int J Clin Exp Med. 2015 Jan 15;8(1):297-303. eCollection 2015.
Associations between Obstructive sleep apnea/hypopnea syndrome (OSAHS) and risk of glaucoma remained controversial. Therefore, we performed this meta-analysis to investigate this association. We searched Pubmed, EMBASE, and Wangfang databases for studies before Oct. 10 2014. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association. A total of 12 studies with 36909 subjects on the association between OSAHS and glaucoma risk were included for this meta-analysis. OSAHS was associated with a significantly increased risk of glaucoma (OR = 1.65; 95% CI, 1.44-1.88; I (2) = 43%). In the race subgroup analysis, both Asians (OR = 1.78; 95% CI, 1.49-2.12; I (2) = 0%) and Caucasians (OR = 2.03; 95% CI, 1.12-3.69; I (2) = 57%) with OSAHS had increased glaucoma risk. In the subgroup analysis according to gender, both women and men were significantly associated with risk of glaucoma (OR = 1.81; 95% CI, 1.27-2.57; I (2) = 22% and OR = 1.62; 95% CI, 1.29-2.03; I (2) = 0%, respectively). In the subgroup analysis by glaucoma type, OSAHS patients showed increased primary open-angle glaucoma (POAG) risk (OR = 1.87; 95% CI, 1.54-2.33; I (2) = 0%) but not normal tension glaucoma (NTG) risk (OR = 3.57; 95% CI, 0.89-14.43; I (2) = 0%). In addition, severe OSAHS patients had an increased glaucoma risk (OR = 5.49; 95% CI, 1.04-33.83; I (2) = 0%), while mild and moderate OSAHS patients did not show significantly increased glaucoma risk. This meta-analysis suggested that the OSAHS may be a risk factor for glaucoma.
阻塞性睡眠呼吸暂停低通气综合征（OSAHS）与青光眼风险之间的关联仍存在争议。因此，我们进行了这项荟萃分析以研究这种关联。我们检索了Pubmed、EMBASE和万方数据库中2014年10月10日前的研究。采用比值比（OR）及95%置信区间（CI）计算关联强度。本荟萃分析共纳入12项研究，涉及36909名受试者，研究OSAHS与青光眼风险之间的关联。OSAHS与青光眼风险显著增加相关（OR = 1.65；95% CI，1.44 - 1.88；I² = 43%）。在种族亚组分析中，患有OSAHS的亚洲人（OR = 1.78；95% CI，1.49 - 2.12；I² = 0%）和高加索人（OR = 2.03；95% CI，1.12 - 3.69；I² = 57%）患青光眼的风险均增加。在按性别进行的亚组分析中，女性和男性均与青光眼风险显著相关（分别为OR = 1.81；95% CI，1.27 - 2.57；I² = 22%和OR = 1.62；95% CI，1.29 - 2.03；I² = 0%）。在按青光眼类型进行的亚组分析中，OSAHS患者原发性开角型青光眼（POAG）风险增加（OR = 1.87；95% CI，1.54 - 2.33；I² = 0%），但正常眼压性青光眼（NTG）风险未增加（OR = 3.57；95% CI，0.89 - 14.43；I² = 0%）。此外，重度OSAHS患者患青光眼的风险增加（OR = 5.49；95% CI，1.04 - 33.83；I² = 0%），而轻度和中度OSAHS患者未显示出青光眼风险显著增加。这项荟萃分析表明，OSAHS可能是青光眼的一个危险因素。
