用于骨再生的生长因子和细胞的控制释放策略。
Strategies for controlled delivery of growth factors and cells for bone regeneration.
机构信息
Department of Bioengineering, Rice University, Houston, TX 77251-1892, USA.
出版信息
Adv Drug Deliv Rev. 2012 Sep;64(12):1292-309. doi: 10.1016/j.addr.2012.01.016. Epub 2012 Feb 4.
Abstract
The controlled delivery of growth factors and cells within biomaterial carriers can enhance and accelerate functional bone formation. The carrier system can be designed with pre-programmed release kinetics to deliver bioactive molecules in a localized, spatiotemporal manner most similar to the natural wound healing process. The carrier can also act as an extracellular matrix-mimicking substrate for promoting osteoprogenitor cellular infiltration and proliferation for integrative tissue repair. This review discusses the role of various regenerative factors involved in bone healing and their appropriate combinations with different delivery systems for augmenting bone regeneration. The general requirements of protein, cell and gene therapy are described, with elaboration on how the selection of materials, configurations and processing affects growth factor and cell delivery and regenerative efficacy in both in vitro and in vivo applications for bone tissue engineering.
摘要
生物材料载体中生长因子和细胞的控制释放可以增强和加速功能性骨形成。载体系统可以设计具有预编程的释放动力学，以局部、时空方式最类似于自然愈合过程的方式递呈生物活性分子。载体还可以充当模仿细胞外基质的底物，以促进成骨细胞前体细胞的渗透和增殖，从而实现整合组织修复。本文讨论了参与骨愈合的各种再生因子的作用，以及它们与不同递释系统的适当组合，以增强骨再生。描述了蛋白、细胞和基因治疗的一般要求，并详细说明了材料、结构和处理的选择如何影响生长因子和细胞的递释以及在骨组织工程的体外和体内应用中的再生效果。
相似文献
1
Strategies for controlled delivery of growth factors and cells for bone regeneration.用于骨再生的生长因子和细胞的控制释放策略。
Adv Drug Deliv Rev. 2012 Sep;64(12):1292-309. doi: 10.1016/j.addr.2012.01.016. Epub 2012 Feb 4.
2
Matrices and scaffolds for delivery of bioactive molecules in bone and cartilage tissue engineering.用于骨和软骨组织工程中生物活性分子递送的基质和支架
Adv Drug Deliv Rev. 2007 May 30;59(4-5):339-59. doi: 10.1016/j.addr.2007.03.016. Epub 2007 Apr 12.
3
Advances in Growth Factor Delivery for Bone Tissue Engineering.生长因子在骨组织工程中的递送进展。
Int J Mol Sci. 2021 Jan 18;22(2):903. doi: 10.3390/ijms22020903.
4
Biomaterial delivery of morphogens to mimic the natural healing cascade in bone.生物材料递呈形态发生素来模拟骨内的自然愈合级联反应。
Adv Drug Deliv Rev. 2012 Sep;64(12):1257-76. doi: 10.1016/j.addr.2012.05.006. Epub 2012 May 22.
5
Growth Factor and Its Polymer Scaffold-Based Delivery System for Cartilage Tissue Engineering.生长因子及其聚合物支架递药系统在软骨组织工程中的应用。
Int J Nanomedicine. 2020 Aug 14;15:6097-6111. doi: 10.2147/IJN.S249829. eCollection 2020.
6
A biomimetic growth factor delivery strategy for enhanced regeneration of iliac crest defects.一种仿生生长因子递释策略，用于增强髂嵴缺损的再生。
Biomed Mater. 2013 Aug;8(4):045009. doi: 10.1088/1748-6041/8/4/045009. Epub 2013 Jun 19.
7
Osteogenic potential of the growth factors and bioactive molecules in bone regeneration.骨再生中生长因子和生物活性分子的成骨潜力。
Int J Biol Macromol. 2021 Apr 1;175:544-557. doi: 10.1016/j.ijbiomac.2021.02.052. Epub 2021 Feb 8.
8
Growth factor delivery: how surface interactions modulate release in vitro and in vivo.生长因子递送：表面相互作用如何调节体外和体内的释放。
Adv Drug Deliv Rev. 2012 Sep;64(12):1239-56. doi: 10.1016/j.addr.2012.03.004. Epub 2012 Mar 10.
9
Dual release scaffolds as a promising strategy for enhancing bone regeneration: an updated review.双释放支架作为促进骨再生的一种有前景的策略：最新综述
Nanomedicine (Lond). 2025 Feb;20(4):371-388. doi: 10.1080/17435889.2025.2457317. Epub 2025 Jan 31.
10
From nano- to macro-scale: nanotechnology approaches for spatially controlled delivery of bioactive factors for bone and cartilage engineering.从纳米到宏观尺度：用于骨和软骨工程中生物活性因子空间控制释放的纳米技术方法。
Nanomedicine (Lond). 2012 Jul;7(7):1045-66. doi: 10.2217/nnm.12.78.
引用本文的文献
1
The Interface of Gene Editing with Regenerative Medicine.基因编辑与再生医学的界面
Engineering (Beijing). 2025 Mar;46:73-100. doi: 10.1016/j.eng.2024.10.019. Epub 2024 Nov 30.
2
Rheological, Structural, and Biological Trade-Offs in Bioink Design for 3D Bioprinting.用于3D生物打印的生物墨水设计中的流变学、结构和生物学权衡
Gels. 2025 Aug 19;11(8):659. doi: 10.3390/gels11080659.
3
Future Frontiers in Bioinspired Implanted Biomaterials.仿生植入生物材料的未来前沿
Adv Mater. 2025 Sep;37(36):e06323. doi: 10.1002/adma.202506323. Epub 2025 Jul 30.
4
Biomaterial-driven regenerative drug delivery: a vicennial bibliometric landscape.生物材料驱动的再生药物递送：二十年文献计量学概述
Front Med (Lausanne). 2025 Jul 14;12:1593985. doi: 10.3389/fmed.2025.1593985. eCollection 2025.
5
Collagen binding properties separate two functionally distinct subpopulations of milk extracellular vesicles regarding bone regenerative capacity.胶原蛋白结合特性将牛奶细胞外囊泡的两个功能不同的亚群在骨再生能力方面区分开来。
Mater Today Bio. 2025 Jul 18;33:102115. doi: 10.1016/j.mtbio.2025.102115. eCollection 2025 Aug.
6
Carbon dots-based drug delivery for bone regeneration.基于碳点的骨再生药物递送
Front Bioeng Biotechnol. 2025 May 29;13:1613901. doi: 10.3389/fbioe.2025.1613901. eCollection 2025.
7
Advancement in smart bone implants: the latest multifunctional strategies and synergistic mechanisms for tissue repair and regeneration.智能骨植入物的进展：组织修复与再生的最新多功能策略及协同机制
Bioact Mater. 2025 May 19;51:333-382. doi: 10.1016/j.bioactmat.2025.05.004. eCollection 2025 Sep.
8
Unveiling the Potential of Single-Cell Encapsulation in Biomedical Applications: Current Advances and Future Perspectives.揭示单细胞封装在生物医学应用中的潜力：当前进展与未来展望。
Small Sci. 2024 Mar 25;4(5):2300332. doi: 10.1002/smsc.202300332. eCollection 2024 May.
9
Challenges of engineering a functional growth plate .构建功能性生长板的挑战。
Front Bioeng Biotechnol. 2025 Mar 4;13:1550713. doi: 10.3389/fbioe.2025.1550713. eCollection 2025.
10
Nanobiotechnology: traditional re-interpreting personalized medicine through targeted therapies and regenerative solutions.纳米生物技术：通过靶向治疗和再生解决方案对个性化医疗进行传统的重新诠释。
Naunyn Schmiedebergs Arch Pharmacol. 2025 Mar 18. doi: 10.1007/s00210-025-04038-6.
本文引用的文献
1
Cell therapy in bone healing disorders.骨愈合障碍中的细胞疗法。
Orthop Rev (Pavia). 2010 Sep 23;2(2):e20. doi: 10.4081/or.2010.e20.
2
Incorporation of PLGA nanoparticles into porous chitosan-gelatin scaffolds: influence on the physical properties and cell behavior.PLGA 纳米粒子掺入多孔壳聚糖-明胶支架中：对物理性能和细胞行为的影响。
J Mech Behav Biomed Mater. 2011 Oct;4(7):1318-27. doi: 10.1016/j.jmbbm.2011.04.019. Epub 2011 May 1.
3
A new growth factor controlled drug release system to promote healing of bone fractures: nanospheres of recombinant human bone morphogenetic-2 and polylactic acid.一种用于促进骨折愈合的新型生长因子控释药物系统：重组人骨形态发生蛋白-2与聚乳酸纳米球
J Nanosci Nanotechnol. 2011 Apr;11(4):3107-14. doi: 10.1166/jnn.2011.3820.
4
Affinity-based growth factor delivery using biodegradable, photocrosslinked heparin-alginate hydrogels.基于亲和性的生长因子递释系统——使用可生物降解的、光交联的肝素-海藻酸钠水凝胶。
J Control Release. 2011 Sep 25;154(3):258-66. doi: 10.1016/j.jconrel.2011.06.027. Epub 2011 Jul 2.
5
A strategy to establish a gene-activated matrix on titanium using gene vectors protected in a polylactide coating.采用聚乳酸涂层保护基因载体的方法在钛上构建基因激活基质的策略。
Biomaterials. 2011 Oct;32(28):6850-9. doi: 10.1016/j.biomaterials.2011.05.071. Epub 2011 Jul 8.
6
In vitro degradation rate of apatitic calcium phosphate cement with incorporated PLGA microspheres.载聚乳酸-羟基乙酸微球的磷酸钙骨水泥体外降解率。
Acta Biomater. 2011 Sep;7(9):3459-68. doi: 10.1016/j.actbio.2011.05.036. Epub 2011 Jun 6.
7
Tunable dual growth factor delivery from polyelectrolyte multilayer films.可调谐的聚电解质多层膜中双重生长因子的释放。
Biomaterials. 2011 Sep;32(26):6183-93. doi: 10.1016/j.biomaterials.2011.04.036. Epub 2011 Jun 8.
8
Creation of bony microenvironment with CaP and cell-derived ECM to enhance human bone-marrow MSC behavior and delivery of BMP-2.用 CaP 和细胞衍生的细胞外基质构建骨微环境，以增强人骨髓间充质干细胞的行为和 BMP-2 的递送。
Biomaterials. 2011 Sep;32(26):6119-30. doi: 10.1016/j.biomaterials.2011.05.015. Epub 2011 May 31.
9
Engineering biomaterial systems to enhance viral vector gene delivery.工程化生物材料系统以增强病毒载体基因传递。
Mol Ther. 2011 Aug;19(8):1407-15. doi: 10.1038/mt.2011.111. Epub 2011 May 31.
10
Harnessing and modulating inflammation in strategies for bone regeneration.利用和调节炎症反应在骨再生策略中的作用。
Tissue Eng Part B Rev. 2011 Dec;17(6):393-402. doi: 10.1089/ten.TEB.2011.0182. Epub 2011 Jun 30.
Zotero 插件