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自噬相关蛋白（ATX）在发育中的大脑中的非细胞自主和非催化活性。

Non-cell autonomous and non-catalytic activities of ATX in the developing brain.

作者信息

Greenman Raanan, Gorelik Anna, Sapir Tamar, Baumgart Jan, Zamor Vanessa, Segal-Salto Michal, Levin-Zaidman Smadar, Aidinis Vassilis, Aoki Junken, Nitsch Robert, Vogt Johannes, Reiner Orly

机构信息

Department of Molecular Genetics, Weizmann Institute of Science Rehovot, Israel.

University Medical Center, Institute for Microscopic Anatomy and Neurobiology, Johannes Gutenberg-University Mainz Mainz, Germany ; Central Laboratory Animal Facility, University Medical Center, Johannes Gutenberg-University Mainz Mainz, Germany.

出版信息

Front Neurosci. 2015 Mar 4;9:53. doi: 10.3389/fnins.2015.00053. eCollection 2015.

DOI:10.3389/fnins.2015.00053
PMID:25788872
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4349085/
Abstract

The intricate formation of the cerebral cortex requires a well-coordinated series of events, which are regulated at the level of cell-autonomous and non-cell autonomous mechanisms. Whereas cell-autonomous mechanisms that regulate cortical development are well-studied, the non-cell autonomous mechanisms remain poorly understood. A non-biased screen allowed us to identify Autotaxin (ATX) as a non-cell autonomous regulator of neural stem cells. ATX (also known as ENPP2) is best known to catalyze lysophosphatidic acid (LPA) production. Our results demonstrate that ATX affects the localization and adhesion of neuronal progenitors in a cell autonomous and non-cell autonomous manner, and strikingly, this activity is independent from its catalytic activity in producing LPA.

摘要

大脑皮层的复杂形成需要一系列协调良好的事件，这些事件在细胞自主和非细胞自主机制层面受到调控。虽然调控皮层发育的细胞自主机制已得到充分研究，但非细胞自主机制仍知之甚少。一项无偏差筛选使我们能够确定自分泌运动因子（ATX）为神经干细胞的非细胞自主调节因子。ATX（也称为ENPP2）最广为人知的作用是催化溶血磷脂酸（LPA）的产生。我们的结果表明，ATX以细胞自主和非细胞自主的方式影响神经元祖细胞的定位和黏附，而且值得注意的是，这种活性与其产生LPA的催化活性无关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c7/4349085/65ac93347636/fnins-09-00053-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c7/4349085/d01079306366/fnins-09-00053-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c7/4349085/7e9fe67fcec2/fnins-09-00053-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c7/4349085/8235fd49a8b2/fnins-09-00053-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c7/4349085/7266d0f0373a/fnins-09-00053-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c7/4349085/a4719c075e5b/fnins-09-00053-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c7/4349085/9e0d49794bdf/fnins-09-00053-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c7/4349085/1ac1b81e45bb/fnins-09-00053-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c7/4349085/65ac93347636/fnins-09-00053-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c7/4349085/d01079306366/fnins-09-00053-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c7/4349085/7e9fe67fcec2/fnins-09-00053-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c7/4349085/8235fd49a8b2/fnins-09-00053-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c7/4349085/7266d0f0373a/fnins-09-00053-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c7/4349085/a4719c075e5b/fnins-09-00053-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c7/4349085/9e0d49794bdf/fnins-09-00053-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c7/4349085/1ac1b81e45bb/fnins-09-00053-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c7/4349085/65ac93347636/fnins-09-00053-g0008.jpg

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2
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3
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Int J Mol Sci. 2023 May 5;24(9):8325. doi: 10.3390/ijms24098325.
4
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