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Factors Associated with Intention to Receive Influenza and Tetanus, Diphtheria, and Acellular Pertussis (Tdap) Vaccines during Pregnancy: A Focus on Vaccine Hesitancy and Perceptions of Disease Severity and Vaccine Safety.

作者信息

Chamberlain Allison T, Seib Katherine, Ault Kevin A, Orenstein Walter A, Frew Paula M, Malik Fauzia, Cortés Marielysse, Cota Pat, Whitney Ellen A S, Flowers Lisa C, Berkelman Ruth L, Omer Saad B

机构信息

Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.

Department of Medicine, Division of Infectious Disease, Emory University, Atlanta, Georgia, USA.

出版信息

PLoS Curr. 2015 Feb 25;7:ecurrents.outbreaks.d37b61bceebae5a7a06d40a301cfa819. doi: 10.1371/currents.outbreaks.d37b61bceebae5a7a06d40a301cfa819.


DOI:10.1371/currents.outbreaks.d37b61bceebae5a7a06d40a301cfa819
PMID:25789203
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4353696/
Abstract

BACKGROUND: Improving influenza and tetanus, diphtheria and acellular pertussis (Tdap) vaccine coverage among pregnant women is needed. PURPOSE: To assess factors associated with intention to receive influenza and/or Tdap vaccinations during pregnancy with a focus on perceptions of influenza and pertussis disease severity and influenza vaccine safety. METHODS: Participants were 325 pregnant women in Georgia recruited from December 2012 - April 2013 who had not yet received a 2012/2013 influenza vaccine or a Tdap vaccine while pregnant. Women completed a survey assessing influenza vaccination history, likelihood of receiving antenatal influenza and/or Tdap vaccines, and knowledge, attitudes and beliefs about influenza, pertussis, and their associated vaccines. RESULTS: Seventy-three percent and 81% of women believed influenza and pertussis, respectively, would be serious during pregnancy while 87% and 92% believed influenza and pertussis, respectively, would be serious to their infants. Perception of pertussis severity for their infant was strongly associated with an intention to receive a Tdap vaccine before delivery (p=0.004). Despite perceptions of disease severity for themselves and their infants, only 34% and 44% intended to receive antenatal influenza and Tdap vaccines, respectively. Forty-six percent had low perceptions of safety regarding the influenza vaccine during pregnancy, and compared to women who perceived the influenza vaccine as safe, women who perceived the vaccine as unsafe were less likely to intend to receive antenatal influenza (48% vs. 20%; p < 0.001) or Tdap (53% vs. 33%; p < 0.001) vaccinations. CONCLUSIONS: Results from this baseline survey suggest that while pregnant women who remain unvaccinated against influenza within the first three months of the putative influenza season may be aware of the risks influenza and pertussis pose to themselves and their infants, many remain reluctant to receive influenza and Tdap vaccines antenatally. To improve vaccine uptake in the obstetric setting, our findings support development of evidence-based vaccine promotion interventions which emphasize vaccine safety during pregnancy and mention disease severity in infancy.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec63/4353696/e1cdb2f3b021/Figure-3_031014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec63/4353696/28bdecc120b4/Figure1_031014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec63/4353696/da757894fb5b/Table-1_031814_one-page_001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec63/4353696/644457a6110e/Figure-2_031014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec63/4353696/e1cdb2f3b021/Figure-3_031014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec63/4353696/28bdecc120b4/Figure1_031014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec63/4353696/da757894fb5b/Table-1_031814_one-page_001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec63/4353696/644457a6110e/Figure-2_031014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec63/4353696/e1cdb2f3b021/Figure-3_031014.jpg

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[1]
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Influence of maternal risk perception and vaccination knowledge on childhood vaccination intentions.

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[4]
Exploring the Inherent Heterogeneity of Vaccine Hesitancy: A Study of a Childhood-Vaccine-Hesitant Population.

Vaccines (Basel). 2024-7-25

[5]
Vaccination: Adherence and Hesitancy among Pregnant Women for COVID-19, Pertussis, and Influenza Vaccines.

Vaccines (Basel). 2024-4-17

[6]
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[7]
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[8]
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Maternal Vaccination and Vaccine Hesitancy.

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[10]
Trends and characteristics of Tdap vaccination during pregnancy in Ontario, Canada: a retrospective cohort study.

CMAJ Open. 2022

本文引用的文献

[1]
Effective messages in vaccine promotion: a randomized trial.

Pediatrics. 2014-3-3

[2]
ACOG Committee Opinion No. 566: Update on immunization and pregnancy: tetanus, diphtheria, and pertussis vaccination.

Obstet Gynecol. 2013-6

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ACOG committee opinion no. 558: Integrating immunizations into practice.

Obstet Gynecol. 2013-4

[4]
Influenza vaccine: a safe bet for mother and baby.

Obstet Gynecol. 2013-3

[5]
Updated recommendations for use of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) in pregnant women--Advisory Committee on Immunization Practices (ACIP), 2012.

MMWR Morb Mortal Wkly Rep. 2013-2-22

[6]
The effect of exclusive breast-feeding on respiratory illness in young infants in a maternal immunization trial in Bangladesh.

Pediatr Infect Dis J. 2013-5

[7]
Monitoring seasonal influenza vaccination coverage among pregnant women in the United States.

Am J Obstet Gynecol. 2012-7-9

[8]
Influenza immunization in pregnancy: overcoming patient and health care provider barriers.

Am J Obstet Gynecol. 2012-7-9

[9]
Safety of influenza immunization during pregnancy for the fetus and the neonate.

Am J Obstet Gynecol. 2012-7-11

[10]
Safety of influenza vaccines in pregnant women.

Am J Obstet Gynecol. 2012-7-9

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