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探索妊娠期间破伤风类毒素、白喉类毒素、无细胞百日咳疫苗(Tdap)和流感疫苗的接种情况及其决定因素:一项横断面研究。

Exploring Tdap and influenza vaccine uptake and its determinants in pregnancy: a cross-sectional study.

作者信息

Brillo E, Ciampoletti M, Tosto V, Buonomo E

机构信息

Centre for Research in Perinatal and Reproductive Medicine, University of Perugia, Perugia, Italy.

Department of Biomedicine and Prevention University of Rome Tor Vergata, Rome, Italy.

出版信息

Ann Ig. 2022 Jul-Aug;34(4):358-374. doi: 10.7416/ai.2022.2503. Epub 2022 Feb 24.

Abstract

BACKGROUND

The literature claims that an increased risk of complications from pertussis and influenza exists for pregnant women and infants. Maternal tetanus, diphtheria, and acellular pertussis (Tdap) and influenza vaccines seem to decrease this risk so that several countries are committed to increase vaccination uptake, but not all of them know their own vaccination coverage and factors that motivate this population to vaccination.

STUDY DESIGN

A cross-sectional survey was conducted.

METHODS

We conducted this survey to estimate among pregnant women: 1) the vaccine coverage, 2) the availability of information, 3) the knowledge about maternal Tdap and influenza vaccination, 4) the factors that could have driven unvaccinated pregnant women to have themselves vaccinated. In addition, determinants of Tdap and influenza vaccine uptake and correct knowledge about vaccine-preventable diseases and vaccination in pregnancy were assessed using univariate and multivariate analyses.

RESULTS

Of the 250 women included in the present study, only 58 (23.2%, 95% Confidence Interval (CI): 18-28.4%) and 21 (8.1%, 95% CI: 5-11.8%) reported that they had been vaccinated with Tdap and influenza vaccine, respectively, during their current pregnancy. The most common reasons cited for getting themselves vaccinated was having background knowledge of the health problems due to the diseases prevented by Tdap and influenza vaccines, awareness regarding these vaccines being recommended in pregnancy, knowledge of their effectiveness and/or side effects, and having been informed about vaccination by a healthcare professional.

CONCLUSIONS

Influenza and Tdap vaccine uptake among pregnant women in Italy is low, however, the present study showed that women are available to get vaccinated during pregnancy when adequately informed about the vaccines recommended.

摘要

背景

文献表明,孕妇和婴儿患百日咳和流感并发症的风险增加。孕妇破伤风、白喉和无细胞百日咳(Tdap)疫苗以及流感疫苗似乎可降低这种风险,因此几个国家致力于提高疫苗接种率,但并非所有国家都了解本国的疫苗接种覆盖率以及促使这一人群接种疫苗的因素。

研究设计

开展了一项横断面调查。

方法

我们进行这项调查以估计孕妇群体中的以下情况:1)疫苗接种率;2)信息可得性;3)对孕妇Tdap和流感疫苗的了解;4)可能促使未接种疫苗的孕妇接种疫苗的因素。此外,使用单变量和多变量分析评估了Tdap和流感疫苗接种率的决定因素以及对疫苗可预防疾病和孕期疫苗接种的正确认识。

结果

在本研究纳入的250名女性中,只有58名(23.2%,95%置信区间(CI):18 - 28.4%)和21名(8.1%,95%CI:5 - 11.8%)报告称她们在本次孕期分别接种了Tdap和流感疫苗。接种疫苗最常见的原因是了解Tdap和流感疫苗所预防疾病导致的健康问题、知晓孕期推荐接种这些疫苗、了解其有效性和/或副作用,以及有医疗保健专业人员告知其接种疫苗。

结论

意大利孕妇的流感和Tdap疫苗接种率较低,然而,本研究表明,当充分了解推荐疫苗的相关信息时,女性愿意在孕期接种疫苗。

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