来自软珊瑚艾氏肉芝软珊瑚的多氧化柳珊瑚二萜类化合物。

Polyoxygenated cembrane diterpenoids from the soft coral Sarcophyton ehrenbergi.

作者信息

Cheng Shi-Yie, Wang Shang-Kwei, Hsieh Mu-Keng, Duh Chang-Yih

机构信息

Department of Life Sciences, National University of Kaohsiung, Kaohsiung 811, Taiwan.

Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

出版信息

Int J Mol Sci. 2015 Mar 17;16(3):6140-52. doi: 10.3390/ijms16036140.

DOI:10.3390/ijms16036140

PMID:25789502

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4394524/

Abstract

Five new polyoxygenated cembranoids, named (+)-1,15-epoxy-2-methoxy-12-methoxycarbonyl-11E-sarcophytoxide (1), (+)-2-epi-12-methoxycarbonyl-11E-sarcophine (2), 3,4-epoxyehrenberoxide A (3), ehrenbergol D (4) and ehrenbergol E (5), were obtained from the soft coral Sarcophyton ehrenbergi. The structures of 1-5 were established on the basis of comprehensive NMR and HR-ESI-MS analyses and by comparison with reported data in the literature. Compounds 4 and 5 showed moderate cytotoxicity against P-388 (mouse lymphocytic leukemia) cancer cell line with EC50 values of 2.0 and 3.0 μM, respectively. Compound 2 exhibited slight antiviral activity against HCMV (human cytomegalovirus) with IC50 values of 25.0 μg/mL.

摘要

从软珊瑚埃氏肉芝软珊瑚（Sarcophyton ehrenbergi）中获得了5个新的多氧化西松烷类化合物，分别命名为(+)-1,15-环氧-2-甲氧基-12-甲氧基羰基-11E-肉芝氧化合物（1）、(+)-2-表-12-甲氧基羰基-11E-肉芝碱（2）、3,4-环氧埃氏氧化物A（3）、埃氏醇D（4）和埃氏醇E（5）。通过全面的核磁共振（NMR）和高分辨电喷雾电离质谱（HR-ESI-MS）分析，并与文献报道的数据进行比较，确定了化合物1-5的结构。化合物4和5对P-388（小鼠淋巴细胞白血病）癌细胞系显示出中等细胞毒性，其半数有效浓度（EC50）值分别为2.0和3.0 μM。化合物2对人巨细胞病毒（HCMV）表现出轻微的抗病毒活性，其半数抑制浓度（IC50）值为25.0 μg/mL。