低剂量环磷酰胺和低剂量辐射对小鼠诱导性红细胞自身抗体调节的影响。
Effects of low doses of cyclophosphamide and low doses of irradiation on the regulation of induced erythrocyte autoantibodies in mice.
作者信息
Hutchings P, Naor D, Cooke A
出版信息
Immunology. 1985 Jan;54(1):97-104.
Abstract
This paper describes some of the characteristics of a suppressor cell which is capable of regulating a rat RBC-induced autoantibody response against mouse RBCs. This cell, which appears to function as an inducer of suppression on transfer to naive recipients, is sensitive to low doses of cyclophosphamide, and its generation is affected by low doses of irradiation. However, the recipients of these cells are insensitive to cyclophosphamide treatment, suppression still being induced in such animals.
摘要
本文描述了一种抑制细胞的某些特性，该细胞能够调节大鼠红细胞诱导的针对小鼠红细胞的自身抗体反应。这种细胞在转移至未接触过抗原的受体时似乎起着抑制诱导作用，对低剂量环磷酰胺敏感，其生成受低剂量辐射影响。然而，这些细胞的受体对环磷酰胺治疗不敏感，在此类动物中仍可诱导出抑制作用。
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Anti-erythrocyte autoantibody production in mice associated with the injection of rat erythrocytes.与注射大鼠红细胞相关的小鼠抗红细胞自身抗体产生。
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