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患有X连锁B淋巴细胞缺陷的小鼠中缺乏自身抗原特异性脾抑制细胞。

Lack of autoantigen-specific splenic suppressor cells in mice with an X-linked B-lymphocyte defect.

作者信息

Cooke A, Hutchings P, Marshall-Clarke S

出版信息

Immunology. 1980 Dec;41(4):815-8.

PMID:6161878
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1458296/
Abstract

Male and female progeny of a cross between CBA/N female and BALB/c male mice were tested for their ability to generate autoantigen-specific suppressor cells as a result of stimulation with crossreacting rat RBC. Male mice, hemizygous for the X-linked defect, were unable to generate these antigen-specific suppressor cells, whereas their female littermates behaved like the normal (CBA/Ca x BALB/c)F1 mice.

摘要

对CBA/N雌性小鼠和BALB/c雄性小鼠杂交产生的雄性和雌性后代进行测试，以检测它们在用交叉反应大鼠红细胞刺激后产生自身抗原特异性抑制细胞的能力。携带X连锁缺陷的半合子雄性小鼠无法产生这些抗原特异性抑制细胞，而它们的雌性同窝小鼠表现得与正常的（CBA/Ca×BALB/c）F1小鼠一样。

相似文献

1
Lack of autoantigen-specific splenic suppressor cells in mice with an X-linked B-lymphocyte defect.患有X连锁B淋巴细胞缺陷的小鼠中缺乏自身抗原特异性脾抑制细胞。
Immunology. 1980 Dec;41(4):815-8.
2
Studies on non-H-2-linked lymphocyte-activating determinants. II. Nonexpression of Mls determinants in a mouse strain with an X-linked B lymphocyte immune defect.非H-2连锁淋巴细胞激活决定簇的研究。II. X连锁B淋巴细胞免疫缺陷小鼠品系中Mls决定簇的不表达
J Immunol. 1976 Nov;117(5 Pt.2):1922-6.
3
Induction of T15-specific suppressor T cells in mice with the CBA/N defect by neonatal injection with anti-T15 idiotype antibody.通过新生期注射抗T15独特型抗体在具有CBA/N缺陷的小鼠中诱导T15特异性抑制性T细胞。
J Immunol. 1982 Mar;128(3):1145-8.
4
X-linked B-lymphocyte immune defect in CBA/HN mice. I. Studies of the function and composition of spleen cells.CBA/HN小鼠的X连锁B淋巴细胞免疫缺陷。I. 脾细胞功能与组成的研究
J Exp Med. 1975 Apr 1;141(4):788-803.
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Autoantibody to liver-specific lipoprotein in the mouse: regulation by naturally occurring autoantigen specific suppressor cells.小鼠肝脏特异性脂蛋白自身抗体：天然存在的自身抗原特异性抑制细胞的调节作用
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Sex differences in the regulation of experimentally induced autoantibodies in (NZB x NZW)F1 mice.（新西兰黑鼠×新西兰白鼠）F1代小鼠实验性诱导自身抗体调控中的性别差异。
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B cell heterogeneity. I. A study of B cell subpopulations involved in the reconstitution of an X-linked immune defect of B cell differentiation.B细胞异质性。I. 参与X连锁B细胞分化免疫缺陷重建的B细胞亚群研究。
J Immunol. 1979 May;122(5):1750-6.
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Deficient production of anti-red cell autoantibodies by mice with an X-linked B lymphocyte defect.患有X连锁B淋巴细胞缺陷的小鼠产生抗红细胞自身抗体不足。
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Polyclonal activation of the murine immune system by an antibody to IgD. IV. In vivo activation of B lymphocytes from immune defective CBA/N mice.抗IgD抗体对小鼠免疫系统的多克隆激活。IV. 免疫缺陷CBA/N小鼠B淋巴细胞的体内激活
J Immunol. 1983 Nov;131(5):2226-31.

引用本文的文献

1
Defective regulation of erythrocyte autoantibodies in SJL mice.SJL小鼠中红细胞自身抗体的调节缺陷。
Immunology. 1984 Mar;51(3):489-92.
2
Suppression of induced erythrocyte autoantibodies is dependent on Lyt 1 cells.诱导性红细胞自身抗体的抑制依赖于Lyt 1细胞。
Immunology. 1985 Oct;56(2):269-73.
3
Effects of low doses of cyclophosphamide and low doses of irradiation on the regulation of induced erythrocyte autoantibodies in mice.低剂量环磷酰胺和低剂量辐射对小鼠诱导性红细胞自身抗体调节的影响。
Immunology. 1985 Jan;54(1):97-104.

本文引用的文献

1
Specific and non-specific suppressor cell activity in NZB mice.新西兰黑鼠（NZB）体内特异性和非特异性抑制细胞活性
Immunology. 1980 Jul;40(3):335-42.
2
Further improvements in the plaque technique for detecting single antibody-forming cells.用于检测单个抗体形成细胞的蚀斑技术的进一步改进。
Immunology. 1968 Apr;14(4):599-600.
3
Induction of red cell autoantibodies in normal mice.正常小鼠中红细胞自身抗体的诱导
Nat New Biol. 1973 Jun 13;243(128):213-4. doi: 10.1038/newbio243213a0.
4
Autoimmune haemolytic anaemia induced in mice immunized with rat erythrocytes.用大鼠红细胞免疫小鼠诱导产生的自身免疫性溶血性贫血。
Clin Exp Immunol. 1974 Jun;17(2):319-27.
5
The relationship between antigenic structure and the requirement for thymus-derived cells in the immune response.免疫反应中抗原结构与胸腺依赖性细胞需求之间的关系。
J Exp Med. 1971 Jul 1;134(1):103-19. doi: 10.1084/jem.134.1.103.
6
X-linked B-lymphocyte immune defect in CBA/N mice. II. Studies of the mechanisms underlying the immune defect.CBA/N小鼠的X连锁B淋巴细胞免疫缺陷。II.免疫缺陷潜在机制的研究。
J Exp Med. 1975 Sep 1;142(3):637-50. doi: 10.1084/jem.142.3.637.
7
Deficient production of anti-red cell autoantibodies by mice with an X-linked B lymphocyte defect.患有X连锁B淋巴细胞缺陷的小鼠产生抗红细胞自身抗体不足。
Eur J Immunol. 1979 Oct;9(10):820-3. doi: 10.1002/eji.1830091014.
8
Suppressor T cells in experimental autoimmune haemolytic anaemia.实验性自身免疫性溶血性贫血中的抑制性T细胞。
Nature. 1978 May 11;273(5658):154-5. doi: 10.1038/273154a0.
9
In vitro studies of the genetically determined unresponsiveness to thymus-independent antigens in CBA/N mice.对CBA/N小鼠中与胸腺非依赖性抗原的基因决定无反应性的体外研究。
J Immunol. 1976 Feb;116(2):301-4.