Turk J Med Sci. 2015;45(1):33-7. doi: 10.3906/sag-1310-38.
BACKGROUND/AIM: To compare the protective efficacy of erdosteine and vitamins C and E against renal injury caused by hind limb ischemia-reperfusion (I/R).
Rats were split into 4 groups: group I as the control, group II as I/R, group III as I/R + erdosteine, and group IV as I/R + vitamins C and E. Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities and malondialdehyde (MDA) tissue levels were determined.
MDA levels were found comparable with the control group in groups II and III. However, they were considerably decreased in group IV when compared to group II (P < 0.01). Additionally, SOD, CAT, and GSH-Px activities were considerably (P < 0.05) decreased in group II. While CAT and GSH-Px activities were restored (P <0.01) by vitamin E and C treatment, SOD activity was not significantly affected. While GSH-Px activities were higher (P < 0.05) with erdosteine administration, SOD and CAT activities were unchanged.
The protective effect of vitamins C and E is higher than that of erdosteine treatment in reducing the oxidative stress after renal ischemia in this animal model.
背景/目的：比较厄多司坦与维生素 C 和 E 对后肢缺血再灌注（I/R）引起的肾损伤的保护作用。
将大鼠分为 4 组：第 I 组为对照组，第 II 组为 I/R 组，第 III 组为 I/R+厄多司坦组，第 IV 组为 I/R+维生素 C 和 E 组。测定超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GSH-Px）活性及丙二醛（MDA）组织水平。
与对照组相比，第 II 组和第 III 组的 MDA 水平相当。然而，与第 II 组相比，第 IV 组的 MDA 水平显著降低（P<0.01）。此外，第 II 组的 SOD、CAT 和 GSH-Px 活性显著降低（P<0.05）。虽然维生素 E 和 C 治疗恢复了 CAT 和 GSH-Px 活性（P<0.01），但 SOD 活性没有受到显著影响。厄多司坦给药后 GSH-Px 活性升高（P<0.05），而 SOD 和 CAT 活性不变。
在该动物模型中，维生素 C 和 E 的保护作用高于厄多司坦治疗，可降低肾缺血后氧化应激。
