Turk J Med Sci. 2015;45(1):89-92. doi: 10.3906/sag-1308-3.
BACKGROUND/AIM: Dermatologic findings differ among countries but no sufficient data about Turkish HIV-infected patients exist in the literature. Therefore, our aim in this study was to document the dermatologic manifestations and their relationships with CD4 cell counts among HIV/AIDS patients visiting our clinic for the first time in Istanbul, Turkey.
A retrospective analysis of 306 HIV/AIDS patients (260 men, mean age: 38.3 years) was done in a tertiary hospital in Istanbul from January 2006 to September 2012. Information on age, sex, transmission routes, socioeconomic and educational status, CD4 counts, and dermatologic findings was collected retrospectively from medical records.
Our analyses revealed at least 1 dermatologic disease in 111 of the 306 (36.2%) patients. Mean CD4 count of the patients was 393.64 cells/mm3 (range: 4-1270 cells/mm3). Oral candidiasis (12.4%), herpes zoster (5.9%), dermatophytosis (5.4%), hyperpigmentation (5.2%), and folliculitis (4.6%) were the most common skin problems. Statistically significant correlation (P < 0.05) with low CD4 cell counts was found for oral candidiasis, folliculitis, herpes zoster, hyperpigmentation, xerosis, and Kaposi's sarcoma.
Dermatologic manifestations in this study were identical to those described in most studies from Asia, and there were more manifestations as the HIV infection progressed and immune functions declined.
背景/目的：皮肤科表现因国家而异，但土耳其 HIV 感染者的相关数据在文献中并不充分。因此，我们旨在记录在土耳其伊斯坦布尔首次就诊的 HIV/AIDS 患者的皮肤科表现及其与 CD4 细胞计数的关系。
在伊斯坦布尔的一家三级医院对 2006 年 1 月至 2012 年 9 月期间的 306 名 HIV/AIDS 患者（260 名男性，平均年龄：38.3 岁）进行回顾性分析。从病历中回顾性收集年龄、性别、传播途径、社会经济和教育状况、CD4 计数和皮肤科表现的信息。
我们的分析显示，在 306 名患者中，至少有 111 名（36.2%）患者患有 1 种以上的皮肤科疾病。患者的平均 CD4 计数为 393.64 个细胞/mm3（范围：4-1270 个细胞/mm3）。口腔念珠菌病（12.4%）、带状疱疹（5.9%）、皮肤癣菌病（5.4%）、色素沉着（5.2%）和滤泡炎（4.6%）是最常见的皮肤问题。口腔念珠菌病、滤泡炎、带状疱疹、色素沉着、干燥和卡波西肉瘤与低 CD4 细胞计数呈统计学显著相关（P<0.05）。
本研究中的皮肤科表现与亚洲大多数研究中的表现相同，随着 HIV 感染的进展和免疫功能的下降，表现会更多。
