Lahoti Sonal, Rao Kavita, Umadevi H S, Mishra Lakshmi
Department of Oral and Maxillofacial Pathology, Vokkaligara Sangha Dental College, Bengaluru, Karnataka, India.
Indian J Dent Res. 2017 Sep-Oct;28(5):549-554. doi: 10.4103/ijdr.IJDR_352_16.
As the search for reliable clinical indicators for management of human immunodeficiency virus/AIDS continues, mucocutaneous manifestations of HIV are considered among key clinical indicators for prediction of underlying degree of immunosuppression, systemic opportunistic infections, and disease progression.
(1) To study the prevalence of mucocutaneous manifestations in HIV-seropositive patients attending the ART center of our hospital (2) To correlate mucocutaneous manifestations with CD4 cell counts.
A total of 200 HIV-seropositive patients of adult age group visiting our hospital were included in the study. Information on demographics such as age, sex, transmission route, socioeconomic status, educational status, CD4 counts, and mucocutaneous findings was collected through interview administered survey and case records followed by oral and cutaneous examination.
Mean CD4 cell count of asymptomatic HIV/AIDS patients was 580.96 cells/mm3. In comparison with the CD4 cell count of asymptomatic HIV-positive patients, (mean 580.96 cells/mm3) CD4 cell count of HIV-positive patients with various mucocutaneous manifestations (mean 409.65 cells/mm3) was correlated using student t-test and was statistically significant (P = 0.017).
This study revealed maximum mucocutaneous lesions in the CD4 count range of 200-500. Nail changes accounted for the most common cutaneous manifestation with 53%, and pigmentation accounted for the most common oral manifestation with 39%. Mucocutaneous manifestations can arouse one to suspect the diagnosis of HIV infection in an otherwise healthy unwary patient. They can serve as a dependable marker of HIV disease.
随着对人类免疫缺陷病毒/艾滋病管理的可靠临床指标的探索仍在继续，HIV的皮肤黏膜表现被视为预测潜在免疫抑制程度、全身性机会性感染和疾病进展的关键临床指标之一。
（1）研究在我院接受抗逆转录病毒治疗中心治疗的HIV血清学阳性患者中皮肤黏膜表现的患病率。（2）将皮肤黏膜表现与CD4细胞计数相关联。
本研究纳入了我院就诊的200名成年年龄组的HIV血清学阳性患者。通过访谈式调查和病例记录收集年龄、性别、传播途径、社会经济状况、教育状况、CD4计数和皮肤黏膜检查结果等人口统计学信息，随后进行口腔和皮肤检查。
无症状HIV/AIDS患者的平均CD4细胞计数为580.96个细胞/mm³。使用学生t检验比较无症状HIV阳性患者的CD4细胞计数（平均580.96个细胞/mm³）与有各种皮肤黏膜表现的HIV阳性患者的CD4细胞计数（平均409.65个细胞/mm³），差异具有统计学意义（P = 0.017）。
本研究显示CD4计数在200 - 500范围内皮肤黏膜病变最多。指甲改变是最常见的皮肤表现，占53%，色素沉着是最常见的口腔表现，占39%。皮肤黏膜表现可促使人们怀疑原本健康但粗心的患者感染了HIV。它们可作为HIV疾病的可靠标志物。
