Turk J Med Sci. 2015;45(1):233-40. doi: 10.3906/sag-1402-71.
BACKGROUND/AIM: Brain ischemia and treatment are important topics in neurological science. Free oxygen radicals and inflammation formed after ischemia are accepted as the most significant causes of damage. Currently there are studies on many chemopreventive agents to prevent cerebral ischemia damage. Our aim is to research the preventive effect of the active ingredient in syringic acid, previously unstudied, on oxidative damage in cerebral ischemia.
The rats were randomly divided into 4 groups: control group (no medication or surgical procedure), sham group (artery occlusion), artery occlusion + syringic acid group sacrificed at 6 h, and artery occlusion + syringic acid group sacrificed at 24 h. Obtained brain tissue from the right hemisphere was investigated histopathologically and for tissue biochemistry.
Superoxide dismutase and nuclear respiratory factor 1 values decreased after ischemia and they increased after syringic acid treatment, while increased malondialdehyde levels after ischemia were reduced after treatment. Caspase-3 and caspase-9 values increased after ischemia and decreased after treatment; this reduction was more pronounced at 24 h.
Our study revealed that syringic acid treatment in cerebral ischemia reduced oxidative stress and neuronal degeneration. In the light of the biochemical and histopathologic results of the present study, we think that syringic acid treatment may be an alternative treatment method.
背景/目的：脑缺血及其治疗是神经科学的重要课题。缺血后形成的游离氧自由基和炎症被认为是造成损伤的最重要原因。目前有许多化学预防剂的研究旨在预防脑缺血损伤。我们的目的是研究之前未研究过的丁香酸活性成分对脑缺血氧化损伤的预防作用。
将大鼠随机分为 4 组：对照组（无药物或手术）、假手术组（动脉闭塞）、动脉闭塞+丁香酸组（6 小时处死）和动脉闭塞+丁香酸组（24 小时处死）。从右侧大脑半球获得脑组织进行组织病理学和组织生物化学研究。
缺血后超氧化物歧化酶和核呼吸因子 1 值下降，丁香酸处理后增加，而缺血后丙二醛水平升高，处理后降低。缺血后 caspase-3 和 caspase-9 值增加，处理后降低；24 小时后降低更明显。
我们的研究表明，丁香酸治疗脑缺血可减轻氧化应激和神经元变性。根据本研究的生化和组织病理学结果，我们认为丁香酸治疗可能是一种替代治疗方法。
